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Genome-wide CRISPR Screening Reveals Pyrimidine Metabolic Reprogramming in 5-FU Chronochemotherapy of Colorectal Cancer

OBJECTIVE: Disruption of the circadian rhythm is associated with cancer occurrence, response to chemotherapy, and poor prognosis. Thus, using internal clock-based chronotherapy to optimize the administration time may improve the therapeutic effects of anticancer drugs while reducing the side effects...

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Detalles Bibliográficos
Autores principales:	Niu, Ya, Fan, Xinyi, Wang, Yaping, Lin, Jiaxin, Hua, Luchun, Li, Xiaobo, Qian, Ruizhe, Lu, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316589/ https://www.ncbi.nlm.nih.gov/pubmed/35903686 http://dx.doi.org/10.3389/fonc.2022.949715

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