Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research

We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to t...

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Autores principales: Olguín, Valeria, Durán, Anyelo, Las Heras, Macarena, Rubilar, Juan Carlos, Cubillos, Francisco A., Olguín, Patricio, Klein, Andrés D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316598/
https://www.ncbi.nlm.nih.gov/pubmed/35886916
http://dx.doi.org/10.3390/ijms23147570
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author Olguín, Valeria
Durán, Anyelo
Las Heras, Macarena
Rubilar, Juan Carlos
Cubillos, Francisco A.
Olguín, Patricio
Klein, Andrés D.
author_facet Olguín, Valeria
Durán, Anyelo
Las Heras, Macarena
Rubilar, Juan Carlos
Cubillos, Francisco A.
Olguín, Patricio
Klein, Andrés D.
author_sort Olguín, Valeria
collection PubMed
description We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly, and yeast panels with insightful applications for translational research.
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spelling pubmed-93165982022-07-27 Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research Olguín, Valeria Durán, Anyelo Las Heras, Macarena Rubilar, Juan Carlos Cubillos, Francisco A. Olguín, Patricio Klein, Andrés D. Int J Mol Sci Review We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly, and yeast panels with insightful applications for translational research. MDPI 2022-07-08 /pmc/articles/PMC9316598/ /pubmed/35886916 http://dx.doi.org/10.3390/ijms23147570 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Olguín, Valeria
Durán, Anyelo
Las Heras, Macarena
Rubilar, Juan Carlos
Cubillos, Francisco A.
Olguín, Patricio
Klein, Andrés D.
Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
title Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
title_full Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
title_fullStr Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
title_full_unstemmed Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
title_short Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
title_sort genetic background matters: population-based studies in model organisms for translational research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316598/
https://www.ncbi.nlm.nih.gov/pubmed/35886916
http://dx.doi.org/10.3390/ijms23147570
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