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An investigation of the constancy of effect in Cochrane systematic reviews in context with the assumptions for noninferiority trials

When designing a noninferiority (NI) study one of the most important steps is to set the noninferiority (NI) limit. The NI limit is an acceptable loss of efficacy for a new investigative treatment compared to an active control treatment – often standard care. The limit should be a value so small tha...

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Detalles Bibliográficos
Autores principales: Duro, Enass M., Julious, Steven A., Ren, Shijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316704/
https://www.ncbi.nlm.nih.gov/pubmed/35879673
http://dx.doi.org/10.1186/s12874-022-01684-9