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Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability

BACKGROUND: Cytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome engineering techniques enable direct testing of the effect of induced DNA methylation on endogenous promoters; however, the downstream effects have not yet...

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Detalles Bibliográficos
Autores principales:	de Mendoza, Alex, Nguyen, Trung Viet, Ford, Ethan, Poppe, Daniel, Buckberry, Sam, Pflueger, Jahnvi, Grimmer, Matthew R., Stolzenburg, Sabine, Bogdanovic, Ozren, Oshlack, Alicia, Farnham, Peggy J., Blancafort, Pilar, Lister, Ryan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316731/ https://www.ncbi.nlm.nih.gov/pubmed/35883107 http://dx.doi.org/10.1186/s13059-022-02728-5

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