Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII

A novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase isoforms I, II, IX and XII showed selective activities on the tumor-associated IX and XII isozymes. Molecular modeling studies on selected com...

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Detalles Bibliográficos
Autores principales: Gumus, Arzu, Bozdag, Murat, Akdemir, Atilla, Angeli, Andrea, Selleri, Silvia, Carta, Fabrizio, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316761/
https://www.ncbi.nlm.nih.gov/pubmed/35889480
http://dx.doi.org/10.3390/molecules27144610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316761/
https://www.ncbi.nlm.nih.gov/pubmed/35889480
http://dx.doi.org/10.3390/molecules27144610

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