Insights on the Modulation of SIRT5 Activity: A Challenging Balance

SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological...

Descripción completa

Detalles Bibliográficos
Autores principales: Mori, Matteo, Cazzaniga, Giulia, Meneghetti, Fiorella, Villa, Stefania, Gelain, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316768/
https://www.ncbi.nlm.nih.gov/pubmed/35889322
http://dx.doi.org/10.3390/molecules27144449
_version_ 1784754895719497728
author Mori, Matteo
Cazzaniga, Giulia
Meneghetti, Fiorella
Villa, Stefania
Gelain, Arianna
author_facet Mori, Matteo
Cazzaniga, Giulia
Meneghetti, Fiorella
Villa, Stefania
Gelain, Arianna
author_sort Mori, Matteo
collection PubMed
description SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field.
format Online
Article
Text
id pubmed-9316768
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93167682022-07-27 Insights on the Modulation of SIRT5 Activity: A Challenging Balance Mori, Matteo Cazzaniga, Giulia Meneghetti, Fiorella Villa, Stefania Gelain, Arianna Molecules Review SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field. MDPI 2022-07-12 /pmc/articles/PMC9316768/ /pubmed/35889322 http://dx.doi.org/10.3390/molecules27144449 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mori, Matteo
Cazzaniga, Giulia
Meneghetti, Fiorella
Villa, Stefania
Gelain, Arianna
Insights on the Modulation of SIRT5 Activity: A Challenging Balance
title Insights on the Modulation of SIRT5 Activity: A Challenging Balance
title_full Insights on the Modulation of SIRT5 Activity: A Challenging Balance
title_fullStr Insights on the Modulation of SIRT5 Activity: A Challenging Balance
title_full_unstemmed Insights on the Modulation of SIRT5 Activity: A Challenging Balance
title_short Insights on the Modulation of SIRT5 Activity: A Challenging Balance
title_sort insights on the modulation of sirt5 activity: a challenging balance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316768/
https://www.ncbi.nlm.nih.gov/pubmed/35889322
http://dx.doi.org/10.3390/molecules27144449
work_keys_str_mv AT morimatteo insightsonthemodulationofsirt5activityachallengingbalance
AT cazzanigagiulia insightsonthemodulationofsirt5activityachallengingbalance
AT meneghettifiorella insightsonthemodulationofsirt5activityachallengingbalance
AT villastefania insightsonthemodulationofsirt5activityachallengingbalance
AT gelainarianna insightsonthemodulationofsirt5activityachallengingbalance

Ejemplares similares