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ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
In the last two years, our world experienced one of the most devastating and fast-exploding pandemic, due to the wide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The scientific community managed to develop effective vaccines, the main weapons to shield the immune system a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316790/ https://www.ncbi.nlm.nih.gov/pubmed/35888159 http://dx.doi.org/10.3390/life12071072 |
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author | Christodoulou, Michalis Iatridi, Fotini Chalkidis, George Lioulios, Georgios Nikolaidou, Christina Badis, Kostas Fylaktou, Asimina Papagianni, Aikaterini Stangou, Maria |
author_facet | Christodoulou, Michalis Iatridi, Fotini Chalkidis, George Lioulios, Georgios Nikolaidou, Christina Badis, Kostas Fylaktou, Asimina Papagianni, Aikaterini Stangou, Maria |
author_sort | Christodoulou, Michalis |
collection | PubMed |
description | In the last two years, our world experienced one of the most devastating and fast-exploding pandemic, due to the wide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The scientific community managed to develop effective vaccines, the main weapons to shield the immune system and protect people. Nevertheless, both SARS-CoV-2 infection and the vaccination against it have been associated with the stimulation of inflammatory cells such as T and B lymphocytes that results in a cytokine storm, endothelial inflammation and vascular injury, which can lead to different types of vasculitis. We present the first case of de novo MPO-ANCA-associated vasculitis, which developed shortly after SARS-CoV-2 vaccination, adequately responded to treatment, and subsequently relapsed after COVID-19 infection. With this case, we indicate an etiological connection between viral infection and disease development, as well as the possibility of a common immune mechanism between SARS-CoV-2 infection and vaccination, that can stimulate vascular events and lead to vasculitis. There have been several case reports of de novo vasculitis, affecting large, medium, or small vessels, following either infection or vaccination against COVID-19, during the pandemic outbreak. We summarize previous reports and also analyze proposed pathogenic mechanisms between SARS-CoV-2 and vasculitis. |
format | Online Article Text |
id | pubmed-9316790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93167902022-07-27 ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination Christodoulou, Michalis Iatridi, Fotini Chalkidis, George Lioulios, Georgios Nikolaidou, Christina Badis, Kostas Fylaktou, Asimina Papagianni, Aikaterini Stangou, Maria Life (Basel) Case Report In the last two years, our world experienced one of the most devastating and fast-exploding pandemic, due to the wide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The scientific community managed to develop effective vaccines, the main weapons to shield the immune system and protect people. Nevertheless, both SARS-CoV-2 infection and the vaccination against it have been associated with the stimulation of inflammatory cells such as T and B lymphocytes that results in a cytokine storm, endothelial inflammation and vascular injury, which can lead to different types of vasculitis. We present the first case of de novo MPO-ANCA-associated vasculitis, which developed shortly after SARS-CoV-2 vaccination, adequately responded to treatment, and subsequently relapsed after COVID-19 infection. With this case, we indicate an etiological connection between viral infection and disease development, as well as the possibility of a common immune mechanism between SARS-CoV-2 infection and vaccination, that can stimulate vascular events and lead to vasculitis. There have been several case reports of de novo vasculitis, affecting large, medium, or small vessels, following either infection or vaccination against COVID-19, during the pandemic outbreak. We summarize previous reports and also analyze proposed pathogenic mechanisms between SARS-CoV-2 and vasculitis. MDPI 2022-07-18 /pmc/articles/PMC9316790/ /pubmed/35888159 http://dx.doi.org/10.3390/life12071072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Christodoulou, Michalis Iatridi, Fotini Chalkidis, George Lioulios, Georgios Nikolaidou, Christina Badis, Kostas Fylaktou, Asimina Papagianni, Aikaterini Stangou, Maria ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination |
title | ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination |
title_full | ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination |
title_fullStr | ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination |
title_full_unstemmed | ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination |
title_short | ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination |
title_sort | anca-associated vasculitis may result as a complication to both sars-cov-2 infection and vaccination |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316790/ https://www.ncbi.nlm.nih.gov/pubmed/35888159 http://dx.doi.org/10.3390/life12071072 |
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