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ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination

In the last two years, our world experienced one of the most devastating and fast-exploding pandemic, due to the wide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The scientific community managed to develop effective vaccines, the main weapons to shield the immune system a...

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Autores principales: Christodoulou, Michalis, Iatridi, Fotini, Chalkidis, George, Lioulios, Georgios, Nikolaidou, Christina, Badis, Kostas, Fylaktou, Asimina, Papagianni, Aikaterini, Stangou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316790/
https://www.ncbi.nlm.nih.gov/pubmed/35888159
http://dx.doi.org/10.3390/life12071072
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author Christodoulou, Michalis
Iatridi, Fotini
Chalkidis, George
Lioulios, Georgios
Nikolaidou, Christina
Badis, Kostas
Fylaktou, Asimina
Papagianni, Aikaterini
Stangou, Maria
author_facet Christodoulou, Michalis
Iatridi, Fotini
Chalkidis, George
Lioulios, Georgios
Nikolaidou, Christina
Badis, Kostas
Fylaktou, Asimina
Papagianni, Aikaterini
Stangou, Maria
author_sort Christodoulou, Michalis
collection PubMed
description In the last two years, our world experienced one of the most devastating and fast-exploding pandemic, due to the wide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The scientific community managed to develop effective vaccines, the main weapons to shield the immune system and protect people. Nevertheless, both SARS-CoV-2 infection and the vaccination against it have been associated with the stimulation of inflammatory cells such as T and B lymphocytes that results in a cytokine storm, endothelial inflammation and vascular injury, which can lead to different types of vasculitis. We present the first case of de novo MPO-ANCA-associated vasculitis, which developed shortly after SARS-CoV-2 vaccination, adequately responded to treatment, and subsequently relapsed after COVID-19 infection. With this case, we indicate an etiological connection between viral infection and disease development, as well as the possibility of a common immune mechanism between SARS-CoV-2 infection and vaccination, that can stimulate vascular events and lead to vasculitis. There have been several case reports of de novo vasculitis, affecting large, medium, or small vessels, following either infection or vaccination against COVID-19, during the pandemic outbreak. We summarize previous reports and also analyze proposed pathogenic mechanisms between SARS-CoV-2 and vasculitis.
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spelling pubmed-93167902022-07-27 ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination Christodoulou, Michalis Iatridi, Fotini Chalkidis, George Lioulios, Georgios Nikolaidou, Christina Badis, Kostas Fylaktou, Asimina Papagianni, Aikaterini Stangou, Maria Life (Basel) Case Report In the last two years, our world experienced one of the most devastating and fast-exploding pandemic, due to the wide spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The scientific community managed to develop effective vaccines, the main weapons to shield the immune system and protect people. Nevertheless, both SARS-CoV-2 infection and the vaccination against it have been associated with the stimulation of inflammatory cells such as T and B lymphocytes that results in a cytokine storm, endothelial inflammation and vascular injury, which can lead to different types of vasculitis. We present the first case of de novo MPO-ANCA-associated vasculitis, which developed shortly after SARS-CoV-2 vaccination, adequately responded to treatment, and subsequently relapsed after COVID-19 infection. With this case, we indicate an etiological connection between viral infection and disease development, as well as the possibility of a common immune mechanism between SARS-CoV-2 infection and vaccination, that can stimulate vascular events and lead to vasculitis. There have been several case reports of de novo vasculitis, affecting large, medium, or small vessels, following either infection or vaccination against COVID-19, during the pandemic outbreak. We summarize previous reports and also analyze proposed pathogenic mechanisms between SARS-CoV-2 and vasculitis. MDPI 2022-07-18 /pmc/articles/PMC9316790/ /pubmed/35888159 http://dx.doi.org/10.3390/life12071072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Christodoulou, Michalis
Iatridi, Fotini
Chalkidis, George
Lioulios, Georgios
Nikolaidou, Christina
Badis, Kostas
Fylaktou, Asimina
Papagianni, Aikaterini
Stangou, Maria
ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
title ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
title_full ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
title_fullStr ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
title_full_unstemmed ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
title_short ANCA-Associated Vasculitis May Result as a Complication to Both SARS-CoV-2 Infection and Vaccination
title_sort anca-associated vasculitis may result as a complication to both sars-cov-2 infection and vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316790/
https://www.ncbi.nlm.nih.gov/pubmed/35888159
http://dx.doi.org/10.3390/life12071072
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