Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency

The formation of a tetrameric assembly is essential for the ability of the tumor suppressor protein p53 to act as a transcription factor. Such a quaternary conformation is driven by a specific tetramerization domain, separated from the central DNA-binding domain by a flexible linker. Despite the dis...

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Detalles Bibliográficos
Autores principales: Rigoli, Marta, Spagnolli, Giovanni, Lorengo, Giulia, Monti, Paola, Potestio, Raffaello, Biasini, Emiliano, Inga, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316806/
https://www.ncbi.nlm.nih.gov/pubmed/35887312
http://dx.doi.org/10.3390/ijms23147960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316806/
https://www.ncbi.nlm.nih.gov/pubmed/35887312
http://dx.doi.org/10.3390/ijms23147960

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