Cargando…
Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency
The formation of a tetrameric assembly is essential for the ability of the tumor suppressor protein p53 to act as a transcription factor. Such a quaternary conformation is driven by a specific tetramerization domain, separated from the central DNA-binding domain by a flexible linker. Despite the dis...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316806/ https://www.ncbi.nlm.nih.gov/pubmed/35887312 http://dx.doi.org/10.3390/ijms23147960 |