Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic s...

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Autores principales: Gubatan, John, Boye, Theresa Louise, Temby, Michelle, Sojwal, Raoul S., Holman, Derek R., Sinha, Sidhartha R., Rogalla, Stephan R., Nielsen, Ole Haagen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316834/
https://www.ncbi.nlm.nih.gov/pubmed/35889090
http://dx.doi.org/10.3390/microorganisms10071371
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author Gubatan, John
Boye, Theresa Louise
Temby, Michelle
Sojwal, Raoul S.
Holman, Derek R.
Sinha, Sidhartha R.
Rogalla, Stephan R.
Nielsen, Ole Haagen
author_facet Gubatan, John
Boye, Theresa Louise
Temby, Michelle
Sojwal, Raoul S.
Holman, Derek R.
Sinha, Sidhartha R.
Rogalla, Stephan R.
Nielsen, Ole Haagen
author_sort Gubatan, John
collection PubMed
description The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer.
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spelling pubmed-93168342022-07-27 Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer Gubatan, John Boye, Theresa Louise Temby, Michelle Sojwal, Raoul S. Holman, Derek R. Sinha, Sidhartha R. Rogalla, Stephan R. Nielsen, Ole Haagen Microorganisms Review The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer. MDPI 2022-07-07 /pmc/articles/PMC9316834/ /pubmed/35889090 http://dx.doi.org/10.3390/microorganisms10071371 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gubatan, John
Boye, Theresa Louise
Temby, Michelle
Sojwal, Raoul S.
Holman, Derek R.
Sinha, Sidhartha R.
Rogalla, Stephan R.
Nielsen, Ole Haagen
Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
title Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
title_full Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
title_fullStr Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
title_full_unstemmed Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
title_short Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
title_sort gut microbiome in inflammatory bowel disease: role in pathogenesis, dietary modulation, and colitis-associated colon cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316834/
https://www.ncbi.nlm.nih.gov/pubmed/35889090
http://dx.doi.org/10.3390/microorganisms10071371
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