Cargando…

Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database

We aimed to evaluate the clinical course and impact of the SARS-CoV-2 pandemic on the rate of diagnosis and therapy in the complete Polish population of patients (pts) with pulmonary arterial hypertension (PAH-1134) and CTEPH (570 pts) treated within the National Health Fund program and reported in...

Descripción completa

Detalles Bibliográficos
Autores principales: Mamzer, Aleksandra, Waligora, Marcin, Kopec, Grzegorz, Ptaszynska-Kopczynska, Katarzyna, Kurzyna, Marcin, Darocha, Szymon, Florczyk, Michal, Mroczek, Ewa, Mularek-Kubzdela, Tatiana, Smukowska-Gorynia, Anna, Wrotynski, Michal, Chrzanowski, Lukasz, Dzikowska-Diduch, Olga, Perzanowska-Brzeszkiewicz, Katarzyna, Pruszczyk, Piotr, Skoczylas, Ilona, Lewicka, Ewa, Blaszczak, Piotr, Karasek, Danuta, Kusmierczyk-Droszcz, Beata, Mizia-Stec, Katarzyna, Kaminski, Karol, Jachec, Wojciech, Peregud-Pogorzelska, Malgorzata, Doboszynska, Anna, Gasior, Zbigniew, Tomaszewski, Michal, Pawlak, Agnieszka, Zablocka, Wieslawa, Ryczek, Robert, Widejko-Pietkiewicz, Katarzyna, Kasprzak, Jaroslaw D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316841/
https://www.ncbi.nlm.nih.gov/pubmed/35886278
http://dx.doi.org/10.3390/ijerph19148423
_version_ 1784754913068187648
author Mamzer, Aleksandra
Waligora, Marcin
Kopec, Grzegorz
Ptaszynska-Kopczynska, Katarzyna
Kurzyna, Marcin
Darocha, Szymon
Florczyk, Michal
Mroczek, Ewa
Mularek-Kubzdela, Tatiana
Smukowska-Gorynia, Anna
Wrotynski, Michal
Chrzanowski, Lukasz
Dzikowska-Diduch, Olga
Perzanowska-Brzeszkiewicz, Katarzyna
Pruszczyk, Piotr
Skoczylas, Ilona
Lewicka, Ewa
Blaszczak, Piotr
Karasek, Danuta
Kusmierczyk-Droszcz, Beata
Mizia-Stec, Katarzyna
Kaminski, Karol
Jachec, Wojciech
Peregud-Pogorzelska, Malgorzata
Doboszynska, Anna
Gasior, Zbigniew
Tomaszewski, Michal
Pawlak, Agnieszka
Zablocka, Wieslawa
Ryczek, Robert
Widejko-Pietkiewicz, Katarzyna
Kasprzak, Jaroslaw D.
author_facet Mamzer, Aleksandra
Waligora, Marcin
Kopec, Grzegorz
Ptaszynska-Kopczynska, Katarzyna
Kurzyna, Marcin
Darocha, Szymon
Florczyk, Michal
Mroczek, Ewa
Mularek-Kubzdela, Tatiana
Smukowska-Gorynia, Anna
Wrotynski, Michal
Chrzanowski, Lukasz
Dzikowska-Diduch, Olga
Perzanowska-Brzeszkiewicz, Katarzyna
Pruszczyk, Piotr
Skoczylas, Ilona
Lewicka, Ewa
Blaszczak, Piotr
Karasek, Danuta
Kusmierczyk-Droszcz, Beata
Mizia-Stec, Katarzyna
Kaminski, Karol
Jachec, Wojciech
Peregud-Pogorzelska, Malgorzata
Doboszynska, Anna
Gasior, Zbigniew
Tomaszewski, Michal
Pawlak, Agnieszka
Zablocka, Wieslawa
Ryczek, Robert
Widejko-Pietkiewicz, Katarzyna
Kasprzak, Jaroslaw D.
author_sort Mamzer, Aleksandra
collection PubMed
description We aimed to evaluate the clinical course and impact of the SARS-CoV-2 pandemic on the rate of diagnosis and therapy in the complete Polish population of patients (pts) with pulmonary arterial hypertension (PAH-1134) and CTEPH (570 pts) treated within the National Health Fund program and reported in the national BNP-PL database. Updated records of 1704 BNP-PL pts collected between March and December 2020 were analyzed with regard to incidence, clinical course and mortality associated with COVID-19. Clinical characteristics of the infected pts and COVID-19 decedents were analyzed. The rates of new diagnoses and treatment intensification in this period were studied and collated to the proper intervals of the previous year. The incidence of COVID-19 was 3.8% (n = 65) (PAH, 4.1%; CTEPH, 3.2%). COVID-19-related mortality was 28% (18/65 pts). Those who died were substantially older and had a more advanced functional WHO class and more cardiovascular comorbidities (comorbidity score, 4.0 ± 2.1 vs. 2.7 ± 1.8; p = 0.01). During the pandemic, annualized new diagnoses of PH diminished by 25–30% as compared to 2019. A relevant increase in total mortality was also observed among the PH pts (9.7% vs. 5.9% pre-pandemic, p = 0.006), whereas escalation of specific PAH/CTEPH therapies occurred less frequently (14.7% vs. 21.6% pre-pandemic). The COVID-19 pandemic has affected the diagnosis and treatment of PH by decreasing the number of new diagnoses, escalating therapy and enhancing overall mortality. Pulmonary hypertension is a risk factor for worsened course of COVID-19 and elevated mortality.
format Online
Article
Text
id pubmed-9316841
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93168412022-07-27 Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database Mamzer, Aleksandra Waligora, Marcin Kopec, Grzegorz Ptaszynska-Kopczynska, Katarzyna Kurzyna, Marcin Darocha, Szymon Florczyk, Michal Mroczek, Ewa Mularek-Kubzdela, Tatiana Smukowska-Gorynia, Anna Wrotynski, Michal Chrzanowski, Lukasz Dzikowska-Diduch, Olga Perzanowska-Brzeszkiewicz, Katarzyna Pruszczyk, Piotr Skoczylas, Ilona Lewicka, Ewa Blaszczak, Piotr Karasek, Danuta Kusmierczyk-Droszcz, Beata Mizia-Stec, Katarzyna Kaminski, Karol Jachec, Wojciech Peregud-Pogorzelska, Malgorzata Doboszynska, Anna Gasior, Zbigniew Tomaszewski, Michal Pawlak, Agnieszka Zablocka, Wieslawa Ryczek, Robert Widejko-Pietkiewicz, Katarzyna Kasprzak, Jaroslaw D. Int J Environ Res Public Health Article We aimed to evaluate the clinical course and impact of the SARS-CoV-2 pandemic on the rate of diagnosis and therapy in the complete Polish population of patients (pts) with pulmonary arterial hypertension (PAH-1134) and CTEPH (570 pts) treated within the National Health Fund program and reported in the national BNP-PL database. Updated records of 1704 BNP-PL pts collected between March and December 2020 were analyzed with regard to incidence, clinical course and mortality associated with COVID-19. Clinical characteristics of the infected pts and COVID-19 decedents were analyzed. The rates of new diagnoses and treatment intensification in this period were studied and collated to the proper intervals of the previous year. The incidence of COVID-19 was 3.8% (n = 65) (PAH, 4.1%; CTEPH, 3.2%). COVID-19-related mortality was 28% (18/65 pts). Those who died were substantially older and had a more advanced functional WHO class and more cardiovascular comorbidities (comorbidity score, 4.0 ± 2.1 vs. 2.7 ± 1.8; p = 0.01). During the pandemic, annualized new diagnoses of PH diminished by 25–30% as compared to 2019. A relevant increase in total mortality was also observed among the PH pts (9.7% vs. 5.9% pre-pandemic, p = 0.006), whereas escalation of specific PAH/CTEPH therapies occurred less frequently (14.7% vs. 21.6% pre-pandemic). The COVID-19 pandemic has affected the diagnosis and treatment of PH by decreasing the number of new diagnoses, escalating therapy and enhancing overall mortality. Pulmonary hypertension is a risk factor for worsened course of COVID-19 and elevated mortality. MDPI 2022-07-10 /pmc/articles/PMC9316841/ /pubmed/35886278 http://dx.doi.org/10.3390/ijerph19148423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mamzer, Aleksandra
Waligora, Marcin
Kopec, Grzegorz
Ptaszynska-Kopczynska, Katarzyna
Kurzyna, Marcin
Darocha, Szymon
Florczyk, Michal
Mroczek, Ewa
Mularek-Kubzdela, Tatiana
Smukowska-Gorynia, Anna
Wrotynski, Michal
Chrzanowski, Lukasz
Dzikowska-Diduch, Olga
Perzanowska-Brzeszkiewicz, Katarzyna
Pruszczyk, Piotr
Skoczylas, Ilona
Lewicka, Ewa
Blaszczak, Piotr
Karasek, Danuta
Kusmierczyk-Droszcz, Beata
Mizia-Stec, Katarzyna
Kaminski, Karol
Jachec, Wojciech
Peregud-Pogorzelska, Malgorzata
Doboszynska, Anna
Gasior, Zbigniew
Tomaszewski, Michal
Pawlak, Agnieszka
Zablocka, Wieslawa
Ryczek, Robert
Widejko-Pietkiewicz, Katarzyna
Kasprzak, Jaroslaw D.
Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database
title Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database
title_full Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database
title_fullStr Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database
title_full_unstemmed Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database
title_short Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database
title_sort impact of the covid-19 pandemic on pulmonary hypertension patients: insights from the bnp-pl national database
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316841/
https://www.ncbi.nlm.nih.gov/pubmed/35886278
http://dx.doi.org/10.3390/ijerph19148423
work_keys_str_mv AT mamzeraleksandra impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT waligoramarcin impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT kopecgrzegorz impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT ptaszynskakopczynskakatarzyna impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT kurzynamarcin impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT darochaszymon impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT florczykmichal impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT mroczekewa impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT mularekkubzdelatatiana impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT smukowskagoryniaanna impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT wrotynskimichal impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT chrzanowskilukasz impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT dzikowskadiducholga impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT perzanowskabrzeszkiewiczkatarzyna impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT pruszczykpiotr impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT skoczylasilona impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT lewickaewa impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT blaszczakpiotr impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT karasekdanuta impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT kusmierczykdroszczbeata impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT miziasteckatarzyna impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT kaminskikarol impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT jachecwojciech impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT peregudpogorzelskamalgorzata impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT doboszynskaanna impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT gasiorzbigniew impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT tomaszewskimichal impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT pawlakagnieszka impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT zablockawieslawa impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT ryczekrobert impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT widejkopietkiewiczkatarzyna impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase
AT kasprzakjaroslawd impactofthecovid19pandemiconpulmonaryhypertensionpatientsinsightsfromthebnpplnationaldatabase