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Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality. MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein expression by suppressing translation, inducing mRNA cleavage, and promoting mRNA degradation. miR-122 is the most abundant miRNA...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316959/ https://www.ncbi.nlm.nih.gov/pubmed/35890276 http://dx.doi.org/10.3390/pharmaceutics14071380 |
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author | Chun, Kwang-Hoon |
author_facet | Chun, Kwang-Hoon |
author_sort | Chun, Kwang-Hoon |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality. MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein expression by suppressing translation, inducing mRNA cleavage, and promoting mRNA degradation. miR-122 is the most abundant miRNA in the liver and is responsible for several liver-specific functions, including metabolism, cellular growth and differentiation, and hepatitis virus replication. Recent studies have shown that aberrant regulation of miR-122 is a key factor contributing to the development of HCC. In this review, the signaling pathways and the molecular targets of miR-122 involved in the progression of HCC have been summarized, and the importance of miR-122 in therapy has been discussed. |
format | Online Article Text |
id | pubmed-9316959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93169592022-07-27 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma Chun, Kwang-Hoon Pharmaceutics Review Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality. MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein expression by suppressing translation, inducing mRNA cleavage, and promoting mRNA degradation. miR-122 is the most abundant miRNA in the liver and is responsible for several liver-specific functions, including metabolism, cellular growth and differentiation, and hepatitis virus replication. Recent studies have shown that aberrant regulation of miR-122 is a key factor contributing to the development of HCC. In this review, the signaling pathways and the molecular targets of miR-122 involved in the progression of HCC have been summarized, and the importance of miR-122 in therapy has been discussed. MDPI 2022-06-29 /pmc/articles/PMC9316959/ /pubmed/35890276 http://dx.doi.org/10.3390/pharmaceutics14071380 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chun, Kwang-Hoon Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma |
title | Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma |
title_full | Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma |
title_fullStr | Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma |
title_full_unstemmed | Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma |
title_short | Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma |
title_sort | molecular targets and signaling pathways of microrna-122 in hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316959/ https://www.ncbi.nlm.nih.gov/pubmed/35890276 http://dx.doi.org/10.3390/pharmaceutics14071380 |
work_keys_str_mv | AT chunkwanghoon moleculartargetsandsignalingpathwaysofmicrorna122inhepatocellularcarcinoma |