Unraveling the Diversity of Co-Colonization by CPE

Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized wi...

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Detalles Bibliográficos
Autores principales: Levi, Gabrielle, Lurie-Weinberger, Mor, Keren-Paz, Alona, Andremont, Antoine O., Schwartz, David, Carmeli, Yehuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316973/
https://www.ncbi.nlm.nih.gov/pubmed/35889010
http://dx.doi.org/10.3390/microorganisms10071292
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author Levi, Gabrielle
Lurie-Weinberger, Mor
Keren-Paz, Alona
Andremont, Antoine O.
Schwartz, David
Carmeli, Yehuda
author_facet Levi, Gabrielle
Lurie-Weinberger, Mor
Keren-Paz, Alona
Andremont, Antoine O.
Schwartz, David
Carmeli, Yehuda
author_sort Levi, Gabrielle
collection PubMed
description Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.
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spelling pubmed-93169732022-07-27 Unraveling the Diversity of Co-Colonization by CPE Levi, Gabrielle Lurie-Weinberger, Mor Keren-Paz, Alona Andremont, Antoine O. Schwartz, David Carmeli, Yehuda Microorganisms Case Report Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization. MDPI 2022-06-25 /pmc/articles/PMC9316973/ /pubmed/35889010 http://dx.doi.org/10.3390/microorganisms10071292 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Levi, Gabrielle
Lurie-Weinberger, Mor
Keren-Paz, Alona
Andremont, Antoine O.
Schwartz, David
Carmeli, Yehuda
Unraveling the Diversity of Co-Colonization by CPE
title Unraveling the Diversity of Co-Colonization by CPE
title_full Unraveling the Diversity of Co-Colonization by CPE
title_fullStr Unraveling the Diversity of Co-Colonization by CPE
title_full_unstemmed Unraveling the Diversity of Co-Colonization by CPE
title_short Unraveling the Diversity of Co-Colonization by CPE
title_sort unraveling the diversity of co-colonization by cpe
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316973/
https://www.ncbi.nlm.nih.gov/pubmed/35889010
http://dx.doi.org/10.3390/microorganisms10071292
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