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Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the penetration of most drug molecules. The large mo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317023/ https://www.ncbi.nlm.nih.gov/pubmed/35890174 http://dx.doi.org/10.3390/ph15070877 |
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author | Zhang, Luyu Dong, Zirong Liu, Wenjuan Wu, Xiying He, Haisheng Lu, Yi Wu, Wei Qi, Jianping |
author_facet | Zhang, Luyu Dong, Zirong Liu, Wenjuan Wu, Xiying He, Haisheng Lu, Yi Wu, Wei Qi, Jianping |
author_sort | Zhang, Luyu |
collection | PubMed |
description | Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the penetration of most drug molecules. The large molecular weight, high hydrophilicity, and lability nature of biomacromolecules pose further challenges to their skin penetration. Recently, novel penetration enhancers, nano vesicles, and microneedles have emerged as efficient strategies to deliver biomacromolecules deep into the skin to exert their therapeutic action. This paper reviews the potential application and mechanisms of novel skin delivery strategies with emphasis on the pharmaceutical formulations. |
format | Online Article Text |
id | pubmed-9317023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93170232022-07-27 Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules Zhang, Luyu Dong, Zirong Liu, Wenjuan Wu, Xiying He, Haisheng Lu, Yi Wu, Wei Qi, Jianping Pharmaceuticals (Basel) Review Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the penetration of most drug molecules. The large molecular weight, high hydrophilicity, and lability nature of biomacromolecules pose further challenges to their skin penetration. Recently, novel penetration enhancers, nano vesicles, and microneedles have emerged as efficient strategies to deliver biomacromolecules deep into the skin to exert their therapeutic action. This paper reviews the potential application and mechanisms of novel skin delivery strategies with emphasis on the pharmaceutical formulations. MDPI 2022-07-16 /pmc/articles/PMC9317023/ /pubmed/35890174 http://dx.doi.org/10.3390/ph15070877 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Luyu Dong, Zirong Liu, Wenjuan Wu, Xiying He, Haisheng Lu, Yi Wu, Wei Qi, Jianping Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules |
title | Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules |
title_full | Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules |
title_fullStr | Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules |
title_full_unstemmed | Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules |
title_short | Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules |
title_sort | novel pharmaceutical strategies for enhancing skin penetration of biomacromolecules |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317023/ https://www.ncbi.nlm.nih.gov/pubmed/35890174 http://dx.doi.org/10.3390/ph15070877 |
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