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Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules

Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the penetration of most drug molecules. The large mo...

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Detalles Bibliográficos
Autores principales: Zhang, Luyu, Dong, Zirong, Liu, Wenjuan, Wu, Xiying, He, Haisheng, Lu, Yi, Wu, Wei, Qi, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317023/
https://www.ncbi.nlm.nih.gov/pubmed/35890174
http://dx.doi.org/10.3390/ph15070877
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author Zhang, Luyu
Dong, Zirong
Liu, Wenjuan
Wu, Xiying
He, Haisheng
Lu, Yi
Wu, Wei
Qi, Jianping
author_facet Zhang, Luyu
Dong, Zirong
Liu, Wenjuan
Wu, Xiying
He, Haisheng
Lu, Yi
Wu, Wei
Qi, Jianping
author_sort Zhang, Luyu
collection PubMed
description Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the penetration of most drug molecules. The large molecular weight, high hydrophilicity, and lability nature of biomacromolecules pose further challenges to their skin penetration. Recently, novel penetration enhancers, nano vesicles, and microneedles have emerged as efficient strategies to deliver biomacromolecules deep into the skin to exert their therapeutic action. This paper reviews the potential application and mechanisms of novel skin delivery strategies with emphasis on the pharmaceutical formulations.
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spelling pubmed-93170232022-07-27 Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules Zhang, Luyu Dong, Zirong Liu, Wenjuan Wu, Xiying He, Haisheng Lu, Yi Wu, Wei Qi, Jianping Pharmaceuticals (Basel) Review Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the penetration of most drug molecules. The large molecular weight, high hydrophilicity, and lability nature of biomacromolecules pose further challenges to their skin penetration. Recently, novel penetration enhancers, nano vesicles, and microneedles have emerged as efficient strategies to deliver biomacromolecules deep into the skin to exert their therapeutic action. This paper reviews the potential application and mechanisms of novel skin delivery strategies with emphasis on the pharmaceutical formulations. MDPI 2022-07-16 /pmc/articles/PMC9317023/ /pubmed/35890174 http://dx.doi.org/10.3390/ph15070877 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Luyu
Dong, Zirong
Liu, Wenjuan
Wu, Xiying
He, Haisheng
Lu, Yi
Wu, Wei
Qi, Jianping
Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
title Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
title_full Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
title_fullStr Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
title_full_unstemmed Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
title_short Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
title_sort novel pharmaceutical strategies for enhancing skin penetration of biomacromolecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317023/
https://www.ncbi.nlm.nih.gov/pubmed/35890174
http://dx.doi.org/10.3390/ph15070877
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