Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis

La Crosse virus (LACV) is a major cause of pediatric encephalitis and aseptic meningitis in the Midwestern, Mid-Atlantic, and Southern United States, where it is an emerging pathogen. The LACV Gc glycoprotein plays a critical role in the neuropathogenesis of LACV encephalitis as the putative virus a...

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Detalles Bibliográficos
Autores principales: Hollidge, Bradley S., Salzano, Mary-Virginia, Ibrahim, John M., Fraser, Jonathan W., Wagner, Valentina, Leitner, Nicole E., Weiss, Susan R., Weber, Friedemann, González-Scarano, Francisco, Soldan, Samantha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317099/
https://www.ncbi.nlm.nih.gov/pubmed/35891445
http://dx.doi.org/10.3390/v14071464

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