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Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
Neurodegenerative disorders (NDs) affect a great number of people worldwide and also have a significant socio-economic impact on the aging population. In this context, nanomedicine applied to neurological disorders provides several biotechnological strategies and nanoformulations that improve life e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317100/ https://www.ncbi.nlm.nih.gov/pubmed/35889562 http://dx.doi.org/10.3390/nano12142337 |
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author | Martano, Simona De Matteis, Valeria Cascione, Mariafrancesca Rinaldi, Rosaria |
author_facet | Martano, Simona De Matteis, Valeria Cascione, Mariafrancesca Rinaldi, Rosaria |
author_sort | Martano, Simona |
collection | PubMed |
description | Neurodegenerative disorders (NDs) affect a great number of people worldwide and also have a significant socio-economic impact on the aging population. In this context, nanomedicine applied to neurological disorders provides several biotechnological strategies and nanoformulations that improve life expectancy and the quality of life of patients affected by brain disorders. However, available treatments are limited by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (B–CSFB). In this regard, nanotechnological approaches could overcome these obstacles by updating various aspects (e.g., enhanced drug-delivery efficiency and bioavailability, BBB permeation and targeting the brain parenchyma, minimizing side effects). The aim of this review is to carefully explore the key elements of different neurological disorders and summarize the available nanomaterials applied for neurodegeneration therapy looking at several types of nanocarriers. Moreover, nutraceutical-loaded nanoparticles (NPs) and synthesized NPs using green approaches are also discussed underling the need to adopt eco-friendly procedures with a low environmental impact. The proven antioxidant properties related to several natural products provide an interesting starting point for developing efficient and green nanotools useful for neuroprotection. |
format | Online Article Text |
id | pubmed-9317100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93171002022-07-27 Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration Martano, Simona De Matteis, Valeria Cascione, Mariafrancesca Rinaldi, Rosaria Nanomaterials (Basel) Review Neurodegenerative disorders (NDs) affect a great number of people worldwide and also have a significant socio-economic impact on the aging population. In this context, nanomedicine applied to neurological disorders provides several biotechnological strategies and nanoformulations that improve life expectancy and the quality of life of patients affected by brain disorders. However, available treatments are limited by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (B–CSFB). In this regard, nanotechnological approaches could overcome these obstacles by updating various aspects (e.g., enhanced drug-delivery efficiency and bioavailability, BBB permeation and targeting the brain parenchyma, minimizing side effects). The aim of this review is to carefully explore the key elements of different neurological disorders and summarize the available nanomaterials applied for neurodegeneration therapy looking at several types of nanocarriers. Moreover, nutraceutical-loaded nanoparticles (NPs) and synthesized NPs using green approaches are also discussed underling the need to adopt eco-friendly procedures with a low environmental impact. The proven antioxidant properties related to several natural products provide an interesting starting point for developing efficient and green nanotools useful for neuroprotection. MDPI 2022-07-07 /pmc/articles/PMC9317100/ /pubmed/35889562 http://dx.doi.org/10.3390/nano12142337 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martano, Simona De Matteis, Valeria Cascione, Mariafrancesca Rinaldi, Rosaria Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration |
title | Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration |
title_full | Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration |
title_fullStr | Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration |
title_full_unstemmed | Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration |
title_short | Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration |
title_sort | inorganic nanomaterials versus polymer-based nanoparticles for overcoming neurodegeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317100/ https://www.ncbi.nlm.nih.gov/pubmed/35889562 http://dx.doi.org/10.3390/nano12142337 |
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