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Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration

Neurodegenerative disorders (NDs) affect a great number of people worldwide and also have a significant socio-economic impact on the aging population. In this context, nanomedicine applied to neurological disorders provides several biotechnological strategies and nanoformulations that improve life e...

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Autores principales: Martano, Simona, De Matteis, Valeria, Cascione, Mariafrancesca, Rinaldi, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317100/
https://www.ncbi.nlm.nih.gov/pubmed/35889562
http://dx.doi.org/10.3390/nano12142337
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author Martano, Simona
De Matteis, Valeria
Cascione, Mariafrancesca
Rinaldi, Rosaria
author_facet Martano, Simona
De Matteis, Valeria
Cascione, Mariafrancesca
Rinaldi, Rosaria
author_sort Martano, Simona
collection PubMed
description Neurodegenerative disorders (NDs) affect a great number of people worldwide and also have a significant socio-economic impact on the aging population. In this context, nanomedicine applied to neurological disorders provides several biotechnological strategies and nanoformulations that improve life expectancy and the quality of life of patients affected by brain disorders. However, available treatments are limited by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (B–CSFB). In this regard, nanotechnological approaches could overcome these obstacles by updating various aspects (e.g., enhanced drug-delivery efficiency and bioavailability, BBB permeation and targeting the brain parenchyma, minimizing side effects). The aim of this review is to carefully explore the key elements of different neurological disorders and summarize the available nanomaterials applied for neurodegeneration therapy looking at several types of nanocarriers. Moreover, nutraceutical-loaded nanoparticles (NPs) and synthesized NPs using green approaches are also discussed underling the need to adopt eco-friendly procedures with a low environmental impact. The proven antioxidant properties related to several natural products provide an interesting starting point for developing efficient and green nanotools useful for neuroprotection.
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spelling pubmed-93171002022-07-27 Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration Martano, Simona De Matteis, Valeria Cascione, Mariafrancesca Rinaldi, Rosaria Nanomaterials (Basel) Review Neurodegenerative disorders (NDs) affect a great number of people worldwide and also have a significant socio-economic impact on the aging population. In this context, nanomedicine applied to neurological disorders provides several biotechnological strategies and nanoformulations that improve life expectancy and the quality of life of patients affected by brain disorders. However, available treatments are limited by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (B–CSFB). In this regard, nanotechnological approaches could overcome these obstacles by updating various aspects (e.g., enhanced drug-delivery efficiency and bioavailability, BBB permeation and targeting the brain parenchyma, minimizing side effects). The aim of this review is to carefully explore the key elements of different neurological disorders and summarize the available nanomaterials applied for neurodegeneration therapy looking at several types of nanocarriers. Moreover, nutraceutical-loaded nanoparticles (NPs) and synthesized NPs using green approaches are also discussed underling the need to adopt eco-friendly procedures with a low environmental impact. The proven antioxidant properties related to several natural products provide an interesting starting point for developing efficient and green nanotools useful for neuroprotection. MDPI 2022-07-07 /pmc/articles/PMC9317100/ /pubmed/35889562 http://dx.doi.org/10.3390/nano12142337 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martano, Simona
De Matteis, Valeria
Cascione, Mariafrancesca
Rinaldi, Rosaria
Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
title Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
title_full Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
title_fullStr Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
title_full_unstemmed Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
title_short Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration
title_sort inorganic nanomaterials versus polymer-based nanoparticles for overcoming neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317100/
https://www.ncbi.nlm.nih.gov/pubmed/35889562
http://dx.doi.org/10.3390/nano12142337
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