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Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference
Genetic recombination plays a critical role in the emergence of pathogens with phenotypes such as drug resistance, virulence, and host adaptation. Here, we tested the hypothesis that recombination between sympatric ancestral populations leads to the emergence of divergent variants of the zoonotic pa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317183/ https://www.ncbi.nlm.nih.gov/pubmed/35776423 http://dx.doi.org/10.1093/molbev/msac150 |
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author | Wang, Tianpeng Guo, Yaqiong Roellig, Dawn M Li, Na Santín, Mónica Lombard, Jason Kváč, Martin Naguib, Doaa Zhang, Ziding Feng, Yaoyu Xiao, Lihua |
author_facet | Wang, Tianpeng Guo, Yaqiong Roellig, Dawn M Li, Na Santín, Mónica Lombard, Jason Kváč, Martin Naguib, Doaa Zhang, Ziding Feng, Yaoyu Xiao, Lihua |
author_sort | Wang, Tianpeng |
collection | PubMed |
description | Genetic recombination plays a critical role in the emergence of pathogens with phenotypes such as drug resistance, virulence, and host adaptation. Here, we tested the hypothesis that recombination between sympatric ancestral populations leads to the emergence of divergent variants of the zoonotic parasite Cryptosporidium parvum with modified host ranges. Comparative genomic analyses of 101 isolates have identified seven subpopulations isolated by distance. They appear to be descendants of two ancestral populations, IIa in northwestern Europe and IId from southwestern Asia. Sympatric recombination in areas with both ancestral subtypes and subsequent selective sweeps have led to the emergence of new subpopulations with mosaic genomes and modified host preference. Subtelomeric genes could be involved in the adaptive selection of subpopulations, while copy number variations of genes encoding invasion-associated proteins are potentially associated with modified host ranges. These observations reveal ancestral origins of zoonotic C. parvum and suggest that pathogen import through modern animal farming might promote the emergence of divergent subpopulations of C. parvum with modified host preference. |
format | Online Article Text |
id | pubmed-9317183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-93171832022-07-27 Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference Wang, Tianpeng Guo, Yaqiong Roellig, Dawn M Li, Na Santín, Mónica Lombard, Jason Kváč, Martin Naguib, Doaa Zhang, Ziding Feng, Yaoyu Xiao, Lihua Mol Biol Evol Discoveries Genetic recombination plays a critical role in the emergence of pathogens with phenotypes such as drug resistance, virulence, and host adaptation. Here, we tested the hypothesis that recombination between sympatric ancestral populations leads to the emergence of divergent variants of the zoonotic parasite Cryptosporidium parvum with modified host ranges. Comparative genomic analyses of 101 isolates have identified seven subpopulations isolated by distance. They appear to be descendants of two ancestral populations, IIa in northwestern Europe and IId from southwestern Asia. Sympatric recombination in areas with both ancestral subtypes and subsequent selective sweeps have led to the emergence of new subpopulations with mosaic genomes and modified host preference. Subtelomeric genes could be involved in the adaptive selection of subpopulations, while copy number variations of genes encoding invasion-associated proteins are potentially associated with modified host ranges. These observations reveal ancestral origins of zoonotic C. parvum and suggest that pathogen import through modern animal farming might promote the emergence of divergent subpopulations of C. parvum with modified host preference. Oxford University Press 2022-07-01 /pmc/articles/PMC9317183/ /pubmed/35776423 http://dx.doi.org/10.1093/molbev/msac150 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Discoveries Wang, Tianpeng Guo, Yaqiong Roellig, Dawn M Li, Na Santín, Mónica Lombard, Jason Kváč, Martin Naguib, Doaa Zhang, Ziding Feng, Yaoyu Xiao, Lihua Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference |
title | Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference |
title_full | Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference |
title_fullStr | Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference |
title_full_unstemmed | Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference |
title_short | Sympatric Recombination in Zoonotic Cryptosporidium Leads to Emergence of Populations with Modified Host Preference |
title_sort | sympatric recombination in zoonotic cryptosporidium leads to emergence of populations with modified host preference |
topic | Discoveries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317183/ https://www.ncbi.nlm.nih.gov/pubmed/35776423 http://dx.doi.org/10.1093/molbev/msac150 |
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