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Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study

Structural arterial stiffness can be evaluated with carotid intima-media thickness (CIMT). Functional arterial stiffness can be evaluated with cardio-ankle vascular index (CAVI). A positive association between CIMT and tooth loss has been reported, but no studies have evaluated the association betwe...

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Autores principales: Shimizu, Yuji, Yamanashi, Hirotomo, Kitamura, Masayasu, Miyata, Jun, Nonaka, Fumiaki, Nakamichi, Seiko, Saito, Toshiyuki, Nagata, Yasuhiro, Maeda, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317227/
https://www.ncbi.nlm.nih.gov/pubmed/35887757
http://dx.doi.org/10.3390/jcm11143993
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author Shimizu, Yuji
Yamanashi, Hirotomo
Kitamura, Masayasu
Miyata, Jun
Nonaka, Fumiaki
Nakamichi, Seiko
Saito, Toshiyuki
Nagata, Yasuhiro
Maeda, Takahiro
author_facet Shimizu, Yuji
Yamanashi, Hirotomo
Kitamura, Masayasu
Miyata, Jun
Nonaka, Fumiaki
Nakamichi, Seiko
Saito, Toshiyuki
Nagata, Yasuhiro
Maeda, Takahiro
author_sort Shimizu, Yuji
collection PubMed
description Structural arterial stiffness can be evaluated with carotid intima-media thickness (CIMT). Functional arterial stiffness can be evaluated with cardio-ankle vascular index (CAVI). A positive association between CIMT and tooth loss has been reported, but no studies have evaluated the association between CIMT and tooth loss in relation to functional arterial stiffness (functional atherosclerosis). A cross-sectional study of 1235 Japanese individuals aged 40–89 years was conducted. Tooth loss was defined as being in the lowest tertile for the number of remaining teeth (≤20 in men and ≤19 in women). Functional atherosclerosis was defined as CAVI ≥ 9.0. Independent of known confounding factors, CIMT was positively associated with tooth loss only in participants without functional atherosclerosis. Adjusted odds ratios for tooth loss and a 1 standard deviation increment in CIMT were 1.27 (1.04–1.55) for participants without functional atherosclerosis and 0.99 (0.77–1.26) for participants with functional atherosclerosis. CIMT and functional atherosclerosis had a significant effect on tooth loss; the fully adjusted p-value for the interaction on tooth loss was 0.019. Independent of known confounding factors, CIMT is positively associated with tooth loss only in participants without functional atherosclerosis. This finding helps clarify the influence of the progression of arterial stiffness on tooth loss because the progression of structural atherosclerosis might have a beneficial influence on the maintenance of the microcirculation.
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spelling pubmed-93172272022-07-27 Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study Shimizu, Yuji Yamanashi, Hirotomo Kitamura, Masayasu Miyata, Jun Nonaka, Fumiaki Nakamichi, Seiko Saito, Toshiyuki Nagata, Yasuhiro Maeda, Takahiro J Clin Med Article Structural arterial stiffness can be evaluated with carotid intima-media thickness (CIMT). Functional arterial stiffness can be evaluated with cardio-ankle vascular index (CAVI). A positive association between CIMT and tooth loss has been reported, but no studies have evaluated the association between CIMT and tooth loss in relation to functional arterial stiffness (functional atherosclerosis). A cross-sectional study of 1235 Japanese individuals aged 40–89 years was conducted. Tooth loss was defined as being in the lowest tertile for the number of remaining teeth (≤20 in men and ≤19 in women). Functional atherosclerosis was defined as CAVI ≥ 9.0. Independent of known confounding factors, CIMT was positively associated with tooth loss only in participants without functional atherosclerosis. Adjusted odds ratios for tooth loss and a 1 standard deviation increment in CIMT were 1.27 (1.04–1.55) for participants without functional atherosclerosis and 0.99 (0.77–1.26) for participants with functional atherosclerosis. CIMT and functional atherosclerosis had a significant effect on tooth loss; the fully adjusted p-value for the interaction on tooth loss was 0.019. Independent of known confounding factors, CIMT is positively associated with tooth loss only in participants without functional atherosclerosis. This finding helps clarify the influence of the progression of arterial stiffness on tooth loss because the progression of structural atherosclerosis might have a beneficial influence on the maintenance of the microcirculation. MDPI 2022-07-10 /pmc/articles/PMC9317227/ /pubmed/35887757 http://dx.doi.org/10.3390/jcm11143993 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimizu, Yuji
Yamanashi, Hirotomo
Kitamura, Masayasu
Miyata, Jun
Nonaka, Fumiaki
Nakamichi, Seiko
Saito, Toshiyuki
Nagata, Yasuhiro
Maeda, Takahiro
Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
title Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
title_full Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
title_fullStr Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
title_full_unstemmed Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
title_short Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
title_sort tooth loss and carotid intima-media thickness in relation to functional atherosclerosis: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317227/
https://www.ncbi.nlm.nih.gov/pubmed/35887757
http://dx.doi.org/10.3390/jcm11143993
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