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Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis

The impact of selenium on the course of Hashimoto’s thyroiditis (HT) was mainly assessed by monitoring the titer of antithyroid autoantibodies in most of the studies conducted hitherto. On the other hand, the imbalance in activity of T cells such as Th1, Th2, Th17, and Treg may be relevant in the pa...

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Autores principales: Kryczyk-Kozioł, Jadwiga, Prochownik, Ewelina, Błażewska-Gruszczyk, Anna, Słowiaczek, Marian, Sun, Qian, Schomburg, Lutz, Ochab, Ewa, Bartyzel, Mirosław, Zagrodzki, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317246/
https://www.ncbi.nlm.nih.gov/pubmed/35889825
http://dx.doi.org/10.3390/nu14142869
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author Kryczyk-Kozioł, Jadwiga
Prochownik, Ewelina
Błażewska-Gruszczyk, Anna
Słowiaczek, Marian
Sun, Qian
Schomburg, Lutz
Ochab, Ewa
Bartyzel, Mirosław
Zagrodzki, Paweł
author_facet Kryczyk-Kozioł, Jadwiga
Prochownik, Ewelina
Błażewska-Gruszczyk, Anna
Słowiaczek, Marian
Sun, Qian
Schomburg, Lutz
Ochab, Ewa
Bartyzel, Mirosław
Zagrodzki, Paweł
author_sort Kryczyk-Kozioł, Jadwiga
collection PubMed
description The impact of selenium on the course of Hashimoto’s thyroiditis (HT) was mainly assessed by monitoring the titer of antithyroid autoantibodies in most of the studies conducted hitherto. On the other hand, the imbalance in activity of T cells such as Th1, Th2, Th17, and Treg may be relevant in the pathogenesis of this disease. Hence, the assessment of changes in the secretion of cytokines by these cells during selenium supplementation in patients with HT seems to be an important issue and was the main goal of this study. A further aim was to search for correlations among these cytokines, as well as markers of thyroid function, selenium/iodine status in the body, and other biochemical parameters. The group of 29 women with newly diagnosed Hashimoto’s thyroiditis was supplemented with selenium in a dose of 100 µg/day for 6 months. Immunological parameters: interferon γ, tumor necrosis factor α, chemokine CXCL10, interleukin 4, interleukin 1β, interleukin 17, transforming growth factor β, and C-reactive protein, as well as selenium status parameters were determined in serum twice, i.e., before and after supplementation. Selenium supplementation was associated with a change in the production of two cytokines: interferon γ and interleukin 1β, for which a decrease and an increase in concentration were observed, respectively. The partial least squares (PLS) model revealed the presence of many relevant correlations among analyzed parameters. The stage of HT development, degree of thyroid dysfunction, and selenium supplementation of diet are interdependent factors which shape the profile of some cytokines secreted by cells participating in the autoimmunity process.
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spelling pubmed-93172462022-07-27 Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis Kryczyk-Kozioł, Jadwiga Prochownik, Ewelina Błażewska-Gruszczyk, Anna Słowiaczek, Marian Sun, Qian Schomburg, Lutz Ochab, Ewa Bartyzel, Mirosław Zagrodzki, Paweł Nutrients Article The impact of selenium on the course of Hashimoto’s thyroiditis (HT) was mainly assessed by monitoring the titer of antithyroid autoantibodies in most of the studies conducted hitherto. On the other hand, the imbalance in activity of T cells such as Th1, Th2, Th17, and Treg may be relevant in the pathogenesis of this disease. Hence, the assessment of changes in the secretion of cytokines by these cells during selenium supplementation in patients with HT seems to be an important issue and was the main goal of this study. A further aim was to search for correlations among these cytokines, as well as markers of thyroid function, selenium/iodine status in the body, and other biochemical parameters. The group of 29 women with newly diagnosed Hashimoto’s thyroiditis was supplemented with selenium in a dose of 100 µg/day for 6 months. Immunological parameters: interferon γ, tumor necrosis factor α, chemokine CXCL10, interleukin 4, interleukin 1β, interleukin 17, transforming growth factor β, and C-reactive protein, as well as selenium status parameters were determined in serum twice, i.e., before and after supplementation. Selenium supplementation was associated with a change in the production of two cytokines: interferon γ and interleukin 1β, for which a decrease and an increase in concentration were observed, respectively. The partial least squares (PLS) model revealed the presence of many relevant correlations among analyzed parameters. The stage of HT development, degree of thyroid dysfunction, and selenium supplementation of diet are interdependent factors which shape the profile of some cytokines secreted by cells participating in the autoimmunity process. MDPI 2022-07-13 /pmc/articles/PMC9317246/ /pubmed/35889825 http://dx.doi.org/10.3390/nu14142869 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kryczyk-Kozioł, Jadwiga
Prochownik, Ewelina
Błażewska-Gruszczyk, Anna
Słowiaczek, Marian
Sun, Qian
Schomburg, Lutz
Ochab, Ewa
Bartyzel, Mirosław
Zagrodzki, Paweł
Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis
title Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis
title_full Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis
title_fullStr Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis
title_full_unstemmed Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis
title_short Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis
title_sort assessment of the effect of selenium supplementation on production of selected cytokines in women with hashimoto’s thyroiditis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317246/
https://www.ncbi.nlm.nih.gov/pubmed/35889825
http://dx.doi.org/10.3390/nu14142869
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