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Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study

Cognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients ≥65 years referred for radiotherapy (RT), we aimed to investigate the association between patient- and cancer-related factors and co...

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Autores principales: Eriksen, Guro Falk, Šaltytė Benth, Jūratė, Grønberg, Bjørn Henning, Rostoft, Siri, Kirkevold, Øyvind, Bergh, Sverre, Hjelstuen, Anne, Rolfson, Darryl, Slaaen, Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317354/
https://www.ncbi.nlm.nih.gov/pubmed/35877269
http://dx.doi.org/10.3390/curroncol29070409
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author Eriksen, Guro Falk
Šaltytė Benth, Jūratė
Grønberg, Bjørn Henning
Rostoft, Siri
Kirkevold, Øyvind
Bergh, Sverre
Hjelstuen, Anne
Rolfson, Darryl
Slaaen, Marit
author_facet Eriksen, Guro Falk
Šaltytė Benth, Jūratė
Grønberg, Bjørn Henning
Rostoft, Siri
Kirkevold, Øyvind
Bergh, Sverre
Hjelstuen, Anne
Rolfson, Darryl
Slaaen, Marit
author_sort Eriksen, Guro Falk
collection PubMed
description Cognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients ≥65 years referred for radiotherapy (RT), we aimed to investigate the association between patient- and cancer-related factors and cognitive function, as evaluated by the Montreal Cognitive Assessment (MoCA), and sought to identify groups with distinct MoCA trajectories. The MoCA was performed at baseline (T0), RT completion (T1), and 8 (T2) and 16 (T3) weeks later, with scores ranging between 0 and 30 and higher scores indicating better function. Linear regression and growth mixture models were estimated to assess associations and to identify groups with distinct MoCA trajectories, respectively. Among 298 patients with a mean age of 73.6 years (SD 6.3), the baseline mean MoCA score was 24.0 (SD 3.7). Compared to Norwegian norm data, 37.9% had cognitive impairment. Compromised cognition was independently associated with older age, lower education, and physical impairments. Four groups with distinct trajectories were identified: the very poor (6.4%), poor (8.1%), fair (37.9%), and good (47.7%) groups. The MoCA trajectories were mainly stable. We conclude that cognitive impairment was frequent but, for most patients, was not affected by RT. For older patients with cancer, and in particular for those with physical impairments, we recommend an assessment of cognitive function.
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spelling pubmed-93173542022-07-27 Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study Eriksen, Guro Falk Šaltytė Benth, Jūratė Grønberg, Bjørn Henning Rostoft, Siri Kirkevold, Øyvind Bergh, Sverre Hjelstuen, Anne Rolfson, Darryl Slaaen, Marit Curr Oncol Article Cognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients ≥65 years referred for radiotherapy (RT), we aimed to investigate the association between patient- and cancer-related factors and cognitive function, as evaluated by the Montreal Cognitive Assessment (MoCA), and sought to identify groups with distinct MoCA trajectories. The MoCA was performed at baseline (T0), RT completion (T1), and 8 (T2) and 16 (T3) weeks later, with scores ranging between 0 and 30 and higher scores indicating better function. Linear regression and growth mixture models were estimated to assess associations and to identify groups with distinct MoCA trajectories, respectively. Among 298 patients with a mean age of 73.6 years (SD 6.3), the baseline mean MoCA score was 24.0 (SD 3.7). Compared to Norwegian norm data, 37.9% had cognitive impairment. Compromised cognition was independently associated with older age, lower education, and physical impairments. Four groups with distinct trajectories were identified: the very poor (6.4%), poor (8.1%), fair (37.9%), and good (47.7%) groups. The MoCA trajectories were mainly stable. We conclude that cognitive impairment was frequent but, for most patients, was not affected by RT. For older patients with cancer, and in particular for those with physical impairments, we recommend an assessment of cognitive function. MDPI 2022-07-21 /pmc/articles/PMC9317354/ /pubmed/35877269 http://dx.doi.org/10.3390/curroncol29070409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eriksen, Guro Falk
Šaltytė Benth, Jūratė
Grønberg, Bjørn Henning
Rostoft, Siri
Kirkevold, Øyvind
Bergh, Sverre
Hjelstuen, Anne
Rolfson, Darryl
Slaaen, Marit
Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
title Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
title_full Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
title_fullStr Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
title_full_unstemmed Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
title_short Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
title_sort cognitive trajectories in older patients with cancer undergoing radiotherapy—a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317354/
https://www.ncbi.nlm.nih.gov/pubmed/35877269
http://dx.doi.org/10.3390/curroncol29070409
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