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Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317389/ https://www.ncbi.nlm.nih.gov/pubmed/35887155 http://dx.doi.org/10.3390/ijms23147807 |
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author | Martínez-Gallego, Irene Rodríguez-Moreno, Antonio Andrade-Talavera, Yuniesky |
author_facet | Martínez-Gallego, Irene Rodríguez-Moreno, Antonio Andrade-Talavera, Yuniesky |
author_sort | Martínez-Gallego, Irene |
collection | PubMed |
description | Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors. |
format | Online Article Text |
id | pubmed-9317389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93173892022-07-27 Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity Martínez-Gallego, Irene Rodríguez-Moreno, Antonio Andrade-Talavera, Yuniesky Int J Mol Sci Opinion Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors. MDPI 2022-07-15 /pmc/articles/PMC9317389/ /pubmed/35887155 http://dx.doi.org/10.3390/ijms23147807 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Martínez-Gallego, Irene Rodríguez-Moreno, Antonio Andrade-Talavera, Yuniesky Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity |
title | Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity |
title_full | Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity |
title_fullStr | Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity |
title_full_unstemmed | Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity |
title_short | Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity |
title_sort | role of group i metabotropic glutamate receptors in spike timing-dependent plasticity |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317389/ https://www.ncbi.nlm.nih.gov/pubmed/35887155 http://dx.doi.org/10.3390/ijms23147807 |
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