Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review

There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown their potential to inhi...

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Autores principales: Borgeat, Alain, Aguirre, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317419/
https://www.ncbi.nlm.nih.gov/pubmed/35888601
http://dx.doi.org/10.3390/medicina58070882
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author Borgeat, Alain
Aguirre, José
author_facet Borgeat, Alain
Aguirre, José
author_sort Borgeat, Alain
collection PubMed
description There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown their potential to inhibit the Intercellular Adhesion Molecule 1 (ICAM-1) expression and Src activity, which are clearly implicated in the process of inflammation and cancer metastases. This review emphasizes the potential of amide-type local anesthetics in this context.
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spelling pubmed-93174192022-07-27 Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review Borgeat, Alain Aguirre, José Medicina (Kaunas) Review There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown their potential to inhibit the Intercellular Adhesion Molecule 1 (ICAM-1) expression and Src activity, which are clearly implicated in the process of inflammation and cancer metastases. This review emphasizes the potential of amide-type local anesthetics in this context. MDPI 2022-06-30 /pmc/articles/PMC9317419/ /pubmed/35888601 http://dx.doi.org/10.3390/medicina58070882 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Borgeat, Alain
Aguirre, José
Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
title Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
title_full Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
title_fullStr Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
title_full_unstemmed Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
title_short Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review
title_sort impact of local anesthetics on cancer behavior and outcome during the perioperative period: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317419/
https://www.ncbi.nlm.nih.gov/pubmed/35888601
http://dx.doi.org/10.3390/medicina58070882
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