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The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
Peripheral artery disease (PAD) is prevalent among individuals with a history of tobacco smoking. Although oxidation of lipids may contribute to atherogenesis in vascular disease, enzymatically and nonenzymatically produced oxidized lipids can have varying and contrasting physiological effects. The...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317423/ https://www.ncbi.nlm.nih.gov/pubmed/35888750 http://dx.doi.org/10.3390/metabo12070627 |
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author | Caligiuri, Stephanie P. B. Pierce, Grant N. Ravandi, Amir Aukema, Harold M. |
author_facet | Caligiuri, Stephanie P. B. Pierce, Grant N. Ravandi, Amir Aukema, Harold M. |
author_sort | Caligiuri, Stephanie P. B. |
collection | PubMed |
description | Peripheral artery disease (PAD) is prevalent among individuals with a history of tobacco smoking. Although oxidation of lipids may contribute to atherogenesis in vascular disease, enzymatically and nonenzymatically produced oxidized lipids can have varying and contrasting physiological effects. The underlying mechanisms of atherogenic vulnerability can be better elucidated with the recent advances in oxylipidome quantification using HPLC-MS/MS technology. In a randomized, controlled clinical trial, the plasma oxylipidome was analyzed in participants living with PAD by smoking status (n = 98) and in nonsmoking comparators without chronic disease (n = 20). Individuals with PAD had approximately a four-fold higher level of total plasma oxylipins versus the comparator. Cessation of smoking in individuals with PAD was associated with significantly lower levels of linoleic acid-derived TriHOMEs, greater levels of omega-3 fatty acid-derived oxylipins, and greater levels of nonfragmented oxidized phosphatidylcholines (OxPCs). Individuals living with PAD but without a history of smoking, exhibited higher levels of the putative atherogenic fragmented OxPCs versus individuals who currently or previously smoked. These data implicate the plasma oxylipidome in PAD and that smoking cessation is associated with a less inflammatory profile. Furthermore, fragmented OxPCs may play a more significant role in the pathophysiology of PAD in individuals without a history of smoking. |
format | Online Article Text |
id | pubmed-9317423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93174232022-07-27 The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease Caligiuri, Stephanie P. B. Pierce, Grant N. Ravandi, Amir Aukema, Harold M. Metabolites Article Peripheral artery disease (PAD) is prevalent among individuals with a history of tobacco smoking. Although oxidation of lipids may contribute to atherogenesis in vascular disease, enzymatically and nonenzymatically produced oxidized lipids can have varying and contrasting physiological effects. The underlying mechanisms of atherogenic vulnerability can be better elucidated with the recent advances in oxylipidome quantification using HPLC-MS/MS technology. In a randomized, controlled clinical trial, the plasma oxylipidome was analyzed in participants living with PAD by smoking status (n = 98) and in nonsmoking comparators without chronic disease (n = 20). Individuals with PAD had approximately a four-fold higher level of total plasma oxylipins versus the comparator. Cessation of smoking in individuals with PAD was associated with significantly lower levels of linoleic acid-derived TriHOMEs, greater levels of omega-3 fatty acid-derived oxylipins, and greater levels of nonfragmented oxidized phosphatidylcholines (OxPCs). Individuals living with PAD but without a history of smoking, exhibited higher levels of the putative atherogenic fragmented OxPCs versus individuals who currently or previously smoked. These data implicate the plasma oxylipidome in PAD and that smoking cessation is associated with a less inflammatory profile. Furthermore, fragmented OxPCs may play a more significant role in the pathophysiology of PAD in individuals without a history of smoking. MDPI 2022-07-07 /pmc/articles/PMC9317423/ /pubmed/35888750 http://dx.doi.org/10.3390/metabo12070627 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Caligiuri, Stephanie P. B. Pierce, Grant N. Ravandi, Amir Aukema, Harold M. The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease |
title | The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease |
title_full | The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease |
title_fullStr | The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease |
title_full_unstemmed | The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease |
title_short | The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease |
title_sort | plasma oxylipidome links smoking status to peripheral artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317423/ https://www.ncbi.nlm.nih.gov/pubmed/35888750 http://dx.doi.org/10.3390/metabo12070627 |
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