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The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease

Peripheral artery disease (PAD) is prevalent among individuals with a history of tobacco smoking. Although oxidation of lipids may contribute to atherogenesis in vascular disease, enzymatically and nonenzymatically produced oxidized lipids can have varying and contrasting physiological effects. The...

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Autores principales: Caligiuri, Stephanie P. B., Pierce, Grant N., Ravandi, Amir, Aukema, Harold M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317423/
https://www.ncbi.nlm.nih.gov/pubmed/35888750
http://dx.doi.org/10.3390/metabo12070627
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author Caligiuri, Stephanie P. B.
Pierce, Grant N.
Ravandi, Amir
Aukema, Harold M.
author_facet Caligiuri, Stephanie P. B.
Pierce, Grant N.
Ravandi, Amir
Aukema, Harold M.
author_sort Caligiuri, Stephanie P. B.
collection PubMed
description Peripheral artery disease (PAD) is prevalent among individuals with a history of tobacco smoking. Although oxidation of lipids may contribute to atherogenesis in vascular disease, enzymatically and nonenzymatically produced oxidized lipids can have varying and contrasting physiological effects. The underlying mechanisms of atherogenic vulnerability can be better elucidated with the recent advances in oxylipidome quantification using HPLC-MS/MS technology. In a randomized, controlled clinical trial, the plasma oxylipidome was analyzed in participants living with PAD by smoking status (n = 98) and in nonsmoking comparators without chronic disease (n = 20). Individuals with PAD had approximately a four-fold higher level of total plasma oxylipins versus the comparator. Cessation of smoking in individuals with PAD was associated with significantly lower levels of linoleic acid-derived TriHOMEs, greater levels of omega-3 fatty acid-derived oxylipins, and greater levels of nonfragmented oxidized phosphatidylcholines (OxPCs). Individuals living with PAD but without a history of smoking, exhibited higher levels of the putative atherogenic fragmented OxPCs versus individuals who currently or previously smoked. These data implicate the plasma oxylipidome in PAD and that smoking cessation is associated with a less inflammatory profile. Furthermore, fragmented OxPCs may play a more significant role in the pathophysiology of PAD in individuals without a history of smoking.
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spelling pubmed-93174232022-07-27 The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease Caligiuri, Stephanie P. B. Pierce, Grant N. Ravandi, Amir Aukema, Harold M. Metabolites Article Peripheral artery disease (PAD) is prevalent among individuals with a history of tobacco smoking. Although oxidation of lipids may contribute to atherogenesis in vascular disease, enzymatically and nonenzymatically produced oxidized lipids can have varying and contrasting physiological effects. The underlying mechanisms of atherogenic vulnerability can be better elucidated with the recent advances in oxylipidome quantification using HPLC-MS/MS technology. In a randomized, controlled clinical trial, the plasma oxylipidome was analyzed in participants living with PAD by smoking status (n = 98) and in nonsmoking comparators without chronic disease (n = 20). Individuals with PAD had approximately a four-fold higher level of total plasma oxylipins versus the comparator. Cessation of smoking in individuals with PAD was associated with significantly lower levels of linoleic acid-derived TriHOMEs, greater levels of omega-3 fatty acid-derived oxylipins, and greater levels of nonfragmented oxidized phosphatidylcholines (OxPCs). Individuals living with PAD but without a history of smoking, exhibited higher levels of the putative atherogenic fragmented OxPCs versus individuals who currently or previously smoked. These data implicate the plasma oxylipidome in PAD and that smoking cessation is associated with a less inflammatory profile. Furthermore, fragmented OxPCs may play a more significant role in the pathophysiology of PAD in individuals without a history of smoking. MDPI 2022-07-07 /pmc/articles/PMC9317423/ /pubmed/35888750 http://dx.doi.org/10.3390/metabo12070627 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caligiuri, Stephanie P. B.
Pierce, Grant N.
Ravandi, Amir
Aukema, Harold M.
The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
title The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
title_full The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
title_fullStr The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
title_full_unstemmed The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
title_short The Plasma Oxylipidome Links Smoking Status to Peripheral Artery Disease
title_sort plasma oxylipidome links smoking status to peripheral artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317423/
https://www.ncbi.nlm.nih.gov/pubmed/35888750
http://dx.doi.org/10.3390/metabo12070627
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