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Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease

Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 rat...

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Autores principales: Dolgushina, Nataliya, Gorodnova, Elena, Beznoshenco, Olga, Romanov, Andrey, Menzhinskaya, Irina, Krechetova, Lyubov, Sukhikh, Gennady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317441/
https://www.ncbi.nlm.nih.gov/pubmed/35887770
http://dx.doi.org/10.3390/jcm11144006
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author Dolgushina, Nataliya
Gorodnova, Elena
Beznoshenco, Olga
Romanov, Andrey
Menzhinskaya, Irina
Krechetova, Lyubov
Sukhikh, Gennady
author_facet Dolgushina, Nataliya
Gorodnova, Elena
Beznoshenco, Olga
Romanov, Andrey
Menzhinskaya, Irina
Krechetova, Lyubov
Sukhikh, Gennady
author_sort Dolgushina, Nataliya
collection PubMed
description Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd–7th day of illness (point 1) and 14–28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly.
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spelling pubmed-93174412022-07-27 Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease Dolgushina, Nataliya Gorodnova, Elena Beznoshenco, Olga Romanov, Andrey Menzhinskaya, Irina Krechetova, Lyubov Sukhikh, Gennady J Clin Med Article Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd–7th day of illness (point 1) and 14–28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly. MDPI 2022-07-11 /pmc/articles/PMC9317441/ /pubmed/35887770 http://dx.doi.org/10.3390/jcm11144006 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dolgushina, Nataliya
Gorodnova, Elena
Beznoshenco, Olga
Romanov, Andrey
Menzhinskaya, Irina
Krechetova, Lyubov
Sukhikh, Gennady
Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
title Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
title_full Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
title_fullStr Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
title_full_unstemmed Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
title_short Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
title_sort von willebrand factor and adamts-13 are associated with the severity of covid-19 disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317441/
https://www.ncbi.nlm.nih.gov/pubmed/35887770
http://dx.doi.org/10.3390/jcm11144006
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