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New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully trea...

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Autores principales: Caliceti, Cristiana, Punzo, Angela, Silla, Alessia, Simoni, Patrizia, Roda, Giulia, Hrelia, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317521/
https://www.ncbi.nlm.nih.gov/pubmed/35889921
http://dx.doi.org/10.3390/nu14142964
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author Caliceti, Cristiana
Punzo, Angela
Silla, Alessia
Simoni, Patrizia
Roda, Giulia
Hrelia, Silvana
author_facet Caliceti, Cristiana
Punzo, Angela
Silla, Alessia
Simoni, Patrizia
Roda, Giulia
Hrelia, Silvana
author_sort Caliceti, Cristiana
collection PubMed
description Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence.
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spelling pubmed-93175212022-07-27 New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer Caliceti, Cristiana Punzo, Angela Silla, Alessia Simoni, Patrizia Roda, Giulia Hrelia, Silvana Nutrients Review Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence. MDPI 2022-07-20 /pmc/articles/PMC9317521/ /pubmed/35889921 http://dx.doi.org/10.3390/nu14142964 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Caliceti, Cristiana
Punzo, Angela
Silla, Alessia
Simoni, Patrizia
Roda, Giulia
Hrelia, Silvana
New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
title New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
title_full New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
title_fullStr New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
title_full_unstemmed New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
title_short New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
title_sort new insights into bile acids related signaling pathways in the onset of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317521/
https://www.ncbi.nlm.nih.gov/pubmed/35889921
http://dx.doi.org/10.3390/nu14142964
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