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New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully trea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317521/ https://www.ncbi.nlm.nih.gov/pubmed/35889921 http://dx.doi.org/10.3390/nu14142964 |
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author | Caliceti, Cristiana Punzo, Angela Silla, Alessia Simoni, Patrizia Roda, Giulia Hrelia, Silvana |
author_facet | Caliceti, Cristiana Punzo, Angela Silla, Alessia Simoni, Patrizia Roda, Giulia Hrelia, Silvana |
author_sort | Caliceti, Cristiana |
collection | PubMed |
description | Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence. |
format | Online Article Text |
id | pubmed-9317521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93175212022-07-27 New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer Caliceti, Cristiana Punzo, Angela Silla, Alessia Simoni, Patrizia Roda, Giulia Hrelia, Silvana Nutrients Review Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence. MDPI 2022-07-20 /pmc/articles/PMC9317521/ /pubmed/35889921 http://dx.doi.org/10.3390/nu14142964 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Caliceti, Cristiana Punzo, Angela Silla, Alessia Simoni, Patrizia Roda, Giulia Hrelia, Silvana New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer |
title | New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer |
title_full | New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer |
title_fullStr | New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer |
title_full_unstemmed | New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer |
title_short | New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer |
title_sort | new insights into bile acids related signaling pathways in the onset of colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317521/ https://www.ncbi.nlm.nih.gov/pubmed/35889921 http://dx.doi.org/10.3390/nu14142964 |
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