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Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317532/ https://www.ncbi.nlm.nih.gov/pubmed/35888670 http://dx.doi.org/10.3390/medicina58070951 |
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author | Jung, Susanne Bohner, Lauren Schulte, Miriam Kleinheinz, Johannes |
author_facet | Jung, Susanne Bohner, Lauren Schulte, Miriam Kleinheinz, Johannes |
author_sort | Jung, Susanne |
collection | PubMed |
description | Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an epithelioid RMS diagnosed at the high parietal area of the head. A 71-year-old male patient presented a red-brown pigmented ulcerative nodule in the high parietal region of the head. Previous biopsy and computer tomography imaging revealed a malignant melanoma in stage I (pT2, sN0, Mx). After tumor operation, histological and immunohistochemical analysis of the tumor were conducted. Histological analysis showed an erosive lesion with a monomorphic cell population containing small cells with prominent nucleoli. A positivity was confirmed for CD10, Vimentin, and Desmin. MyoD1 was detected, as well as a fluctuating signal for p53. Molecular analysis revealed a negativity for Sox-10, and a weak positivity for CK8/18 by absence of p40. Based on the morphological and immunohistochemical findings, the tumor was diagnosed as epithelioid RMS. |
format | Online Article Text |
id | pubmed-9317532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93175322022-07-27 Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report Jung, Susanne Bohner, Lauren Schulte, Miriam Kleinheinz, Johannes Medicina (Kaunas) Case Report Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an epithelioid RMS diagnosed at the high parietal area of the head. A 71-year-old male patient presented a red-brown pigmented ulcerative nodule in the high parietal region of the head. Previous biopsy and computer tomography imaging revealed a malignant melanoma in stage I (pT2, sN0, Mx). After tumor operation, histological and immunohistochemical analysis of the tumor were conducted. Histological analysis showed an erosive lesion with a monomorphic cell population containing small cells with prominent nucleoli. A positivity was confirmed for CD10, Vimentin, and Desmin. MyoD1 was detected, as well as a fluctuating signal for p53. Molecular analysis revealed a negativity for Sox-10, and a weak positivity for CK8/18 by absence of p40. Based on the morphological and immunohistochemical findings, the tumor was diagnosed as epithelioid RMS. MDPI 2022-07-19 /pmc/articles/PMC9317532/ /pubmed/35888670 http://dx.doi.org/10.3390/medicina58070951 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Jung, Susanne Bohner, Lauren Schulte, Miriam Kleinheinz, Johannes Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report |
title | Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report |
title_full | Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report |
title_fullStr | Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report |
title_full_unstemmed | Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report |
title_short | Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report |
title_sort | epithelioid rhabdomyosarcoma at the high parietal area of the head: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317532/ https://www.ncbi.nlm.nih.gov/pubmed/35888670 http://dx.doi.org/10.3390/medicina58070951 |
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