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Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report

Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an...

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Autores principales: Jung, Susanne, Bohner, Lauren, Schulte, Miriam, Kleinheinz, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317532/
https://www.ncbi.nlm.nih.gov/pubmed/35888670
http://dx.doi.org/10.3390/medicina58070951
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author Jung, Susanne
Bohner, Lauren
Schulte, Miriam
Kleinheinz, Johannes
author_facet Jung, Susanne
Bohner, Lauren
Schulte, Miriam
Kleinheinz, Johannes
author_sort Jung, Susanne
collection PubMed
description Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an epithelioid RMS diagnosed at the high parietal area of the head. A 71-year-old male patient presented a red-brown pigmented ulcerative nodule in the high parietal region of the head. Previous biopsy and computer tomography imaging revealed a malignant melanoma in stage I (pT2, sN0, Mx). After tumor operation, histological and immunohistochemical analysis of the tumor were conducted. Histological analysis showed an erosive lesion with a monomorphic cell population containing small cells with prominent nucleoli. A positivity was confirmed for CD10, Vimentin, and Desmin. MyoD1 was detected, as well as a fluctuating signal for p53. Molecular analysis revealed a negativity for Sox-10, and a weak positivity for CK8/18 by absence of p40. Based on the morphological and immunohistochemical findings, the tumor was diagnosed as epithelioid RMS.
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spelling pubmed-93175322022-07-27 Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report Jung, Susanne Bohner, Lauren Schulte, Miriam Kleinheinz, Johannes Medicina (Kaunas) Case Report Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an epithelioid RMS diagnosed at the high parietal area of the head. A 71-year-old male patient presented a red-brown pigmented ulcerative nodule in the high parietal region of the head. Previous biopsy and computer tomography imaging revealed a malignant melanoma in stage I (pT2, sN0, Mx). After tumor operation, histological and immunohistochemical analysis of the tumor were conducted. Histological analysis showed an erosive lesion with a monomorphic cell population containing small cells with prominent nucleoli. A positivity was confirmed for CD10, Vimentin, and Desmin. MyoD1 was detected, as well as a fluctuating signal for p53. Molecular analysis revealed a negativity for Sox-10, and a weak positivity for CK8/18 by absence of p40. Based on the morphological and immunohistochemical findings, the tumor was diagnosed as epithelioid RMS. MDPI 2022-07-19 /pmc/articles/PMC9317532/ /pubmed/35888670 http://dx.doi.org/10.3390/medicina58070951 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jung, Susanne
Bohner, Lauren
Schulte, Miriam
Kleinheinz, Johannes
Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
title Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
title_full Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
title_fullStr Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
title_full_unstemmed Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
title_short Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
title_sort epithelioid rhabdomyosarcoma at the high parietal area of the head: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317532/
https://www.ncbi.nlm.nih.gov/pubmed/35888670
http://dx.doi.org/10.3390/medicina58070951
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