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Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms

SIMPLE SUMMARY: Plasmacytoid dendritic cells are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already described and is associated with poor outcomes in cancers. In hematologic...

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Autores principales: Roussel, Xavier, Garnache Ottou, Francine, Renosi, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317563/
https://www.ncbi.nlm.nih.gov/pubmed/35884612
http://dx.doi.org/10.3390/cancers14143545
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author Roussel, Xavier
Garnache Ottou, Francine
Renosi, Florian
author_facet Roussel, Xavier
Garnache Ottou, Francine
Renosi, Florian
author_sort Roussel, Xavier
collection PubMed
description SIMPLE SUMMARY: Plasmacytoid dendritic cells are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already described and is associated with poor outcomes in cancers. In hematological diseases, Blastic Plasmacytoid Dendritic Cells Neoplasm (blastic counterpart) is well described, but little is known about tumor infiltration by mature plasmacytoid dendritic cells described in Myeloid Neoplasms (myeloid tumor cells and clonal pDC proliferation). This review provides a comprehensive overview of plasmacytoid dendritic cells in Myeloid Neoplasms. ABSTRACT: Plasmacytoid dendritic cells (pDC) are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already well described and is associated with poor outcomes in cancers due to the tolerogenic activity of pDC. In hematological diseases, Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN), aggressive leukemia derived from pDCs, is well described, but little is known about tumor infiltration by mature pDC described in Myeloid Neoplasms (MN). Recently, mature pDC proliferation (MPDCP) has been described as a differential diagnosis of BPDCN associated with acute myeloid leukemia (pDC-AML), myelodysplastic syndrome (pDC-MDS) and chronic myelomonocytic leukemia (pDC-CMML). Tumor cells are myeloid blasts and/or mature myeloid cells from related myeloid disorders and pDC derived from a clonal proliferation. The poor prognosis associated with MPDCP requires a better understanding of pDC biology, MN oncogenesis and immune response. This review provides a comprehensive overview about the biological aspects of pDCs, the description of pDC proliferation in MN, and an insight into putative therapies in pDC-AML regarding personalized medicine.
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spelling pubmed-93175632022-07-27 Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms Roussel, Xavier Garnache Ottou, Francine Renosi, Florian Cancers (Basel) Review SIMPLE SUMMARY: Plasmacytoid dendritic cells are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already described and is associated with poor outcomes in cancers. In hematological diseases, Blastic Plasmacytoid Dendritic Cells Neoplasm (blastic counterpart) is well described, but little is known about tumor infiltration by mature plasmacytoid dendritic cells described in Myeloid Neoplasms (myeloid tumor cells and clonal pDC proliferation). This review provides a comprehensive overview of plasmacytoid dendritic cells in Myeloid Neoplasms. ABSTRACT: Plasmacytoid dendritic cells (pDC) are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already well described and is associated with poor outcomes in cancers due to the tolerogenic activity of pDC. In hematological diseases, Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN), aggressive leukemia derived from pDCs, is well described, but little is known about tumor infiltration by mature pDC described in Myeloid Neoplasms (MN). Recently, mature pDC proliferation (MPDCP) has been described as a differential diagnosis of BPDCN associated with acute myeloid leukemia (pDC-AML), myelodysplastic syndrome (pDC-MDS) and chronic myelomonocytic leukemia (pDC-CMML). Tumor cells are myeloid blasts and/or mature myeloid cells from related myeloid disorders and pDC derived from a clonal proliferation. The poor prognosis associated with MPDCP requires a better understanding of pDC biology, MN oncogenesis and immune response. This review provides a comprehensive overview about the biological aspects of pDCs, the description of pDC proliferation in MN, and an insight into putative therapies in pDC-AML regarding personalized medicine. MDPI 2022-07-21 /pmc/articles/PMC9317563/ /pubmed/35884612 http://dx.doi.org/10.3390/cancers14143545 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roussel, Xavier
Garnache Ottou, Francine
Renosi, Florian
Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
title Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
title_full Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
title_fullStr Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
title_full_unstemmed Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
title_short Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms
title_sort plasmacytoid dendritic cells, a novel target in myeloid neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317563/
https://www.ncbi.nlm.nih.gov/pubmed/35884612
http://dx.doi.org/10.3390/cancers14143545
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