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Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery

Acoustic tweezers provide unique capabilities in medical applications, such as contactless manipulation of small objects (e.g., cells, compounds or living things), from nanometer-sized extracellular vesicles to centimeter-scale structures. Additionally, they are capable of being transmitted through...

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Autores principales: Cao, Hiep Xuan, Jung, Daewon, Lee, Han-Sol, Nguyen, Van Du, Choi, Eunpyo, Kang, Byungjeon, Park, Jong-Oh, Kim, Chang-Sei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317593/
https://www.ncbi.nlm.nih.gov/pubmed/35890382
http://dx.doi.org/10.3390/pharmaceutics14071490
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author Cao, Hiep Xuan
Jung, Daewon
Lee, Han-Sol
Nguyen, Van Du
Choi, Eunpyo
Kang, Byungjeon
Park, Jong-Oh
Kim, Chang-Sei
author_facet Cao, Hiep Xuan
Jung, Daewon
Lee, Han-Sol
Nguyen, Van Du
Choi, Eunpyo
Kang, Byungjeon
Park, Jong-Oh
Kim, Chang-Sei
author_sort Cao, Hiep Xuan
collection PubMed
description Acoustic tweezers provide unique capabilities in medical applications, such as contactless manipulation of small objects (e.g., cells, compounds or living things), from nanometer-sized extracellular vesicles to centimeter-scale structures. Additionally, they are capable of being transmitted through the skin to trap and manipulate drug carriers in various media. However, these capabilities are hindered by the limitation of controllable degrees of freedom (DoFs) or are limited maneuverability. In this study, we explore the potential application of acoustical tweezers by presenting a five-DoF contactless manipulation acoustic system (AcoMan). The system has 30 ultrasound transducers (UTs) with single-side arrangement that generates active traveling waves to control the position and orientation of a fully untethered nanocarrier clusters (NCs) in a spherical workspace in water capable of three DoFs translation and two DoFs rotation. In this method, we use a phase modulation algorithm to independently control the phase signal for 30 UTs and manipulate the NCs’ positions. Phase modulation and switching power supply for each UT are employed to rotate the NCs in the horizontal plane and control the amplitude of power supply to each UT to rotate the NCs in the vertical plane. The feasibility of the method is demonstrated by in vitro and ex vivo experiments using porcine ribs. A significant portion of this study could advance the therapeutic application such a system as targeted drug delivery.
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spelling pubmed-93175932022-07-27 Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery Cao, Hiep Xuan Jung, Daewon Lee, Han-Sol Nguyen, Van Du Choi, Eunpyo Kang, Byungjeon Park, Jong-Oh Kim, Chang-Sei Pharmaceutics Article Acoustic tweezers provide unique capabilities in medical applications, such as contactless manipulation of small objects (e.g., cells, compounds or living things), from nanometer-sized extracellular vesicles to centimeter-scale structures. Additionally, they are capable of being transmitted through the skin to trap and manipulate drug carriers in various media. However, these capabilities are hindered by the limitation of controllable degrees of freedom (DoFs) or are limited maneuverability. In this study, we explore the potential application of acoustical tweezers by presenting a five-DoF contactless manipulation acoustic system (AcoMan). The system has 30 ultrasound transducers (UTs) with single-side arrangement that generates active traveling waves to control the position and orientation of a fully untethered nanocarrier clusters (NCs) in a spherical workspace in water capable of three DoFs translation and two DoFs rotation. In this method, we use a phase modulation algorithm to independently control the phase signal for 30 UTs and manipulate the NCs’ positions. Phase modulation and switching power supply for each UT are employed to rotate the NCs in the horizontal plane and control the amplitude of power supply to each UT to rotate the NCs in the vertical plane. The feasibility of the method is demonstrated by in vitro and ex vivo experiments using porcine ribs. A significant portion of this study could advance the therapeutic application such a system as targeted drug delivery. MDPI 2022-07-18 /pmc/articles/PMC9317593/ /pubmed/35890382 http://dx.doi.org/10.3390/pharmaceutics14071490 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cao, Hiep Xuan
Jung, Daewon
Lee, Han-Sol
Nguyen, Van Du
Choi, Eunpyo
Kang, Byungjeon
Park, Jong-Oh
Kim, Chang-Sei
Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery
title Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery
title_full Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery
title_fullStr Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery
title_full_unstemmed Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery
title_short Holographic Acoustic Tweezers for 5-DoF Manipulation of Nanocarrier Clusters toward Targeted Drug Delivery
title_sort holographic acoustic tweezers for 5-dof manipulation of nanocarrier clusters toward targeted drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317593/
https://www.ncbi.nlm.nih.gov/pubmed/35890382
http://dx.doi.org/10.3390/pharmaceutics14071490
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