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Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela

Some of the lineages of SARS-CoV-2, the new coronavirus responsible for COVID-19, exhibit higher transmissibility or partial resistance to antibody-mediated neutralization and were designated by WHO as Variants of Interests (VOIs) or Concern (VOCs). The aim of this study was to monitor the dissemina...

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Autores principales: Jaspe, Rossana C., Loureiro, Carmen L., Sulbaran, Yoneira, Moros, Zoila C., D’Angelo, Pierina, Hidalgo, Mariana, Rodríguez, Lieska, Alarcón, Víctor, Aguilar, Marwan, Sánchez, Doneyla, Ramírez, Jesús, Garzaro, Domingo J., Zambrano, José Luis, Liprandi, Ferdinando, Rangel, Héctor R., Pujol, Flor H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317613/
https://www.ncbi.nlm.nih.gov/pubmed/35891359
http://dx.doi.org/10.3390/v14071378
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author Jaspe, Rossana C.
Loureiro, Carmen L.
Sulbaran, Yoneira
Moros, Zoila C.
D’Angelo, Pierina
Hidalgo, Mariana
Rodríguez, Lieska
Alarcón, Víctor
Aguilar, Marwan
Sánchez, Doneyla
Ramírez, Jesús
Garzaro, Domingo J.
Zambrano, José Luis
Liprandi, Ferdinando
Rangel, Héctor R.
Pujol, Flor H.
author_facet Jaspe, Rossana C.
Loureiro, Carmen L.
Sulbaran, Yoneira
Moros, Zoila C.
D’Angelo, Pierina
Hidalgo, Mariana
Rodríguez, Lieska
Alarcón, Víctor
Aguilar, Marwan
Sánchez, Doneyla
Ramírez, Jesús
Garzaro, Domingo J.
Zambrano, José Luis
Liprandi, Ferdinando
Rangel, Héctor R.
Pujol, Flor H.
author_sort Jaspe, Rossana C.
collection PubMed
description Some of the lineages of SARS-CoV-2, the new coronavirus responsible for COVID-19, exhibit higher transmissibility or partial resistance to antibody-mediated neutralization and were designated by WHO as Variants of Interests (VOIs) or Concern (VOCs). The aim of this study was to monitor the dissemination of VOIs and VOCs in Venezuela from March 2021 to February 2022. A 614 nt genomic fragment was sequenced for the detection of some relevant mutations of these variants. Their presence was confirmed by complete genome sequencing, with a correlation higher than 99% between both methodologies. After the introduction of the Gamma VOC since the beginning of the year 2021, the variants Alpha VOC and Lambda VOI were detected as early as March 2021, at a very low frequency. In contrast, the Mu VOI, detected in May 2021, was able to circulate throughout the country. After the detection of the Delta VOC in June 2021, it became the predominant circulating variant. With the arrival of the Omicron VOC in December, this variant was able to displace the Delta one in less than one month.
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spelling pubmed-93176132022-07-27 Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela Jaspe, Rossana C. Loureiro, Carmen L. Sulbaran, Yoneira Moros, Zoila C. D’Angelo, Pierina Hidalgo, Mariana Rodríguez, Lieska Alarcón, Víctor Aguilar, Marwan Sánchez, Doneyla Ramírez, Jesús Garzaro, Domingo J. Zambrano, José Luis Liprandi, Ferdinando Rangel, Héctor R. Pujol, Flor H. Viruses Article Some of the lineages of SARS-CoV-2, the new coronavirus responsible for COVID-19, exhibit higher transmissibility or partial resistance to antibody-mediated neutralization and were designated by WHO as Variants of Interests (VOIs) or Concern (VOCs). The aim of this study was to monitor the dissemination of VOIs and VOCs in Venezuela from March 2021 to February 2022. A 614 nt genomic fragment was sequenced for the detection of some relevant mutations of these variants. Their presence was confirmed by complete genome sequencing, with a correlation higher than 99% between both methodologies. After the introduction of the Gamma VOC since the beginning of the year 2021, the variants Alpha VOC and Lambda VOI were detected as early as March 2021, at a very low frequency. In contrast, the Mu VOI, detected in May 2021, was able to circulate throughout the country. After the detection of the Delta VOC in June 2021, it became the predominant circulating variant. With the arrival of the Omicron VOC in December, this variant was able to displace the Delta one in less than one month. MDPI 2022-06-24 /pmc/articles/PMC9317613/ /pubmed/35891359 http://dx.doi.org/10.3390/v14071378 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jaspe, Rossana C.
Loureiro, Carmen L.
Sulbaran, Yoneira
Moros, Zoila C.
D’Angelo, Pierina
Hidalgo, Mariana
Rodríguez, Lieska
Alarcón, Víctor
Aguilar, Marwan
Sánchez, Doneyla
Ramírez, Jesús
Garzaro, Domingo J.
Zambrano, José Luis
Liprandi, Ferdinando
Rangel, Héctor R.
Pujol, Flor H.
Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela
title Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela
title_full Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela
title_fullStr Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela
title_full_unstemmed Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela
title_short Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela
title_sort description of a one-year succession of variants of interest and concern of sars-cov-2 in venezuela
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317613/
https://www.ncbi.nlm.nih.gov/pubmed/35891359
http://dx.doi.org/10.3390/v14071378
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