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The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal

Melanin has been reported to have potential applications in industries such as cosmetics and food due to its anti-UV and antioxidative qualities. However, the corresponding data on its safety evaluation or biological consequences are fairly limited; such data are critical given its widespread use. T...

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Autores principales: Andoh, Vivian, Chen, Liang, Zhu, Feifei, Ge, Qi, Ma, Lin, Wang, Qiang, Chen, Keping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317675/
https://www.ncbi.nlm.nih.gov/pubmed/35878159
http://dx.doi.org/10.3390/toxins14070421
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author Andoh, Vivian
Chen, Liang
Zhu, Feifei
Ge, Qi
Ma, Lin
Wang, Qiang
Chen, Keping
author_facet Andoh, Vivian
Chen, Liang
Zhu, Feifei
Ge, Qi
Ma, Lin
Wang, Qiang
Chen, Keping
author_sort Andoh, Vivian
collection PubMed
description Melanin has been reported to have potential applications in industries such as cosmetics and food due to its anti-UV and antioxidative qualities. However, the corresponding data on its safety evaluation or biological consequences are fairly limited; such data are critical given its widespread use. The effect of different concentrations (1, 2, 3, and 4%) of melanin on growth status (larvae length and weight, cocoon weight, and morphology), the microstructure of the various tissues (fat body, silk gland, and midgut), and silk properties was studied by using the silkworm (bombyx mori) as the model organism. The weight and length of silkworm larvae fed with melanin were lower than the control, indicating that melanin appears to have a negative effect on the growth status of silkworms; however, the histophysiology analysis indicates that the cell morphologies are not changed, the XRD and FTIR spectra indicate that the secondary and crystalline structures of silks are also well preserved, and the thermogravimetric analysis and tensile test indicate that the thermal stability and mechanical properties are well maintained and even improved to some extent. Generally, it indicates that melanin has a certain inhibitory effect on the growth of silkworm larva but causes no harm to the cell microstructures or silk properties; this demonstrates that the safety of melanin as a food addictive should be considered seriously. The increase of thermal stability and mechanical properties shows that melanin may be a good chemical modifier in textile industries.
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spelling pubmed-93176752022-07-27 The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal Andoh, Vivian Chen, Liang Zhu, Feifei Ge, Qi Ma, Lin Wang, Qiang Chen, Keping Toxins (Basel) Article Melanin has been reported to have potential applications in industries such as cosmetics and food due to its anti-UV and antioxidative qualities. However, the corresponding data on its safety evaluation or biological consequences are fairly limited; such data are critical given its widespread use. The effect of different concentrations (1, 2, 3, and 4%) of melanin on growth status (larvae length and weight, cocoon weight, and morphology), the microstructure of the various tissues (fat body, silk gland, and midgut), and silk properties was studied by using the silkworm (bombyx mori) as the model organism. The weight and length of silkworm larvae fed with melanin were lower than the control, indicating that melanin appears to have a negative effect on the growth status of silkworms; however, the histophysiology analysis indicates that the cell morphologies are not changed, the XRD and FTIR spectra indicate that the secondary and crystalline structures of silks are also well preserved, and the thermogravimetric analysis and tensile test indicate that the thermal stability and mechanical properties are well maintained and even improved to some extent. Generally, it indicates that melanin has a certain inhibitory effect on the growth of silkworm larva but causes no harm to the cell microstructures or silk properties; this demonstrates that the safety of melanin as a food addictive should be considered seriously. The increase of thermal stability and mechanical properties shows that melanin may be a good chemical modifier in textile industries. MDPI 2022-06-21 /pmc/articles/PMC9317675/ /pubmed/35878159 http://dx.doi.org/10.3390/toxins14070421 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Andoh, Vivian
Chen, Liang
Zhu, Feifei
Ge, Qi
Ma, Lin
Wang, Qiang
Chen, Keping
The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal
title The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal
title_full The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal
title_fullStr The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal
title_full_unstemmed The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal
title_short The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal
title_sort evaluation of the biological effects of melanin by using silkworm as a model animal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317675/
https://www.ncbi.nlm.nih.gov/pubmed/35878159
http://dx.doi.org/10.3390/toxins14070421
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