Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression

Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens’ (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus a...

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Autores principales: Perik-Zavodskii, Roman, Perik-Zavodskaya, Olga, Shevchenko, Yulia, Alrhmoun, Saleh, Volynets, Marina, Zaitsev, Konstantin, Sennikov, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317677/
https://www.ncbi.nlm.nih.gov/pubmed/35886060
http://dx.doi.org/10.3390/genes13071278
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author Perik-Zavodskii, Roman
Perik-Zavodskaya, Olga
Shevchenko, Yulia
Alrhmoun, Saleh
Volynets, Marina
Zaitsev, Konstantin
Sennikov, Sergey
author_facet Perik-Zavodskii, Roman
Perik-Zavodskaya, Olga
Shevchenko, Yulia
Alrhmoun, Saleh
Volynets, Marina
Zaitsev, Konstantin
Sennikov, Sergey
author_sort Perik-Zavodskii, Roman
collection PubMed
description Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens’ (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus and cells expressing the gene have been named extra-thymic AIRE expressing cells (eTACs). Here, we discuss the finding of AIRE and TSAs gene expression in CD71+ cells from human fetal liver parenchyma, which are mostly represented by CD71+ erythroid cells.
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spelling pubmed-93176772022-07-27 Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression Perik-Zavodskii, Roman Perik-Zavodskaya, Olga Shevchenko, Yulia Alrhmoun, Saleh Volynets, Marina Zaitsev, Konstantin Sennikov, Sergey Genes (Basel) Communication Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens’ (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus and cells expressing the gene have been named extra-thymic AIRE expressing cells (eTACs). Here, we discuss the finding of AIRE and TSAs gene expression in CD71+ cells from human fetal liver parenchyma, which are mostly represented by CD71+ erythroid cells. MDPI 2022-07-19 /pmc/articles/PMC9317677/ /pubmed/35886060 http://dx.doi.org/10.3390/genes13071278 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Perik-Zavodskii, Roman
Perik-Zavodskaya, Olga
Shevchenko, Yulia
Alrhmoun, Saleh
Volynets, Marina
Zaitsev, Konstantin
Sennikov, Sergey
Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression
title Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression
title_full Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression
title_fullStr Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression
title_full_unstemmed Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression
title_short Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression
title_sort human fetal liver parenchyma cd71+ cells have aire and tissue-specific antigen gene expression
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317677/
https://www.ncbi.nlm.nih.gov/pubmed/35886060
http://dx.doi.org/10.3390/genes13071278
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