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Fetal Growth Restriction: Comparison of Biometric Parameters
The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter/abdominal circumference (TCD/AC), head circumference/abdominal circumference (HC/A...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317726/ https://www.ncbi.nlm.nih.gov/pubmed/35887622 http://dx.doi.org/10.3390/jpm12071125 |
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author | Marchand, Carolin Köppe, Jeanette Köster, Helen Ann Oelmeier, Kathrin Schmitz, Ralf Steinhard, Johannes Fruscalzo, Arrigo Kubiak, Karol |
author_facet | Marchand, Carolin Köppe, Jeanette Köster, Helen Ann Oelmeier, Kathrin Schmitz, Ralf Steinhard, Johannes Fruscalzo, Arrigo Kubiak, Karol |
author_sort | Marchand, Carolin |
collection | PubMed |
description | The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter/abdominal circumference (TCD/AC), head circumference/abdominal circumference (HC/AC), and femur length/abdominal circumference (FL/AC). In a retrospective single-center cross-sectional study, the biometric data of 9292 pregnancies between the 15th and 42nd weeks of gestation were acquired. Statistical analysis included descriptive data, quantile regression estimating the 10th and 90th percentiles, and multivariable analysis. We obtained clinically noticeable results in predicting small-for-gestational-age (SGA) and fetal growth restriction (FGR) fetuses at advanced weeks of gestation using the AC with a Youden index of 0.81 and 0.96, respectively. The other individual parameters and quotients were less suited to identifying cases of SGA and FGR. The multivariable analysis demonstrated the best results for identifying SGA and FGR fetuses with an area under the curve of 0.95 and 0.96, respectively. The individual ultrasound parameters were better suited to identifying SGA and FGR than the ratios. Amongst these, the AC was the most promising individual parameter, especially at advanced weeks of gestation. However, the highest accuracy was achieved with a multivariable model. |
format | Online Article Text |
id | pubmed-9317726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93177262022-07-27 Fetal Growth Restriction: Comparison of Biometric Parameters Marchand, Carolin Köppe, Jeanette Köster, Helen Ann Oelmeier, Kathrin Schmitz, Ralf Steinhard, Johannes Fruscalzo, Arrigo Kubiak, Karol J Pers Med Article The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter/abdominal circumference (TCD/AC), head circumference/abdominal circumference (HC/AC), and femur length/abdominal circumference (FL/AC). In a retrospective single-center cross-sectional study, the biometric data of 9292 pregnancies between the 15th and 42nd weeks of gestation were acquired. Statistical analysis included descriptive data, quantile regression estimating the 10th and 90th percentiles, and multivariable analysis. We obtained clinically noticeable results in predicting small-for-gestational-age (SGA) and fetal growth restriction (FGR) fetuses at advanced weeks of gestation using the AC with a Youden index of 0.81 and 0.96, respectively. The other individual parameters and quotients were less suited to identifying cases of SGA and FGR. The multivariable analysis demonstrated the best results for identifying SGA and FGR fetuses with an area under the curve of 0.95 and 0.96, respectively. The individual ultrasound parameters were better suited to identifying SGA and FGR than the ratios. Amongst these, the AC was the most promising individual parameter, especially at advanced weeks of gestation. However, the highest accuracy was achieved with a multivariable model. MDPI 2022-07-11 /pmc/articles/PMC9317726/ /pubmed/35887622 http://dx.doi.org/10.3390/jpm12071125 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marchand, Carolin Köppe, Jeanette Köster, Helen Ann Oelmeier, Kathrin Schmitz, Ralf Steinhard, Johannes Fruscalzo, Arrigo Kubiak, Karol Fetal Growth Restriction: Comparison of Biometric Parameters |
title | Fetal Growth Restriction: Comparison of Biometric Parameters |
title_full | Fetal Growth Restriction: Comparison of Biometric Parameters |
title_fullStr | Fetal Growth Restriction: Comparison of Biometric Parameters |
title_full_unstemmed | Fetal Growth Restriction: Comparison of Biometric Parameters |
title_short | Fetal Growth Restriction: Comparison of Biometric Parameters |
title_sort | fetal growth restriction: comparison of biometric parameters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317726/ https://www.ncbi.nlm.nih.gov/pubmed/35887622 http://dx.doi.org/10.3390/jpm12071125 |
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