Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi

[(18)F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the...

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Detalles Bibliográficos
Autores principales: Pacelli, Anna, Zarrad, Fadi, Fendler, Wolfgang P., Herrmann, Ken, Nader, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317788/
https://www.ncbi.nlm.nih.gov/pubmed/35890164
http://dx.doi.org/10.3390/ph15070865
Descripción
Sumario:[(18)F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the previously reported protocol for [(18)F]PARPi synthesis is challenging, as it requires transferring microvolumes of reagents, which many platforms cannot accommodate. We report a revised, high yield, and automated protocol for the radiosynthesis of [(18)F]PARPi, with final doses of over 20 GBq.

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