Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi

[(18)F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the...

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Detalles Bibliográficos
Autores principales: Pacelli, Anna, Zarrad, Fadi, Fendler, Wolfgang P., Herrmann, Ken, Nader, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317788/
https://www.ncbi.nlm.nih.gov/pubmed/35890164
http://dx.doi.org/10.3390/ph15070865
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author Pacelli, Anna
Zarrad, Fadi
Fendler, Wolfgang P.
Herrmann, Ken
Nader, Michael
author_facet Pacelli, Anna
Zarrad, Fadi
Fendler, Wolfgang P.
Herrmann, Ken
Nader, Michael
author_sort Pacelli, Anna
collection PubMed
description [(18)F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the previously reported protocol for [(18)F]PARPi synthesis is challenging, as it requires transferring microvolumes of reagents, which many platforms cannot accommodate. We report a revised, high yield, and automated protocol for the radiosynthesis of [(18)F]PARPi, with final doses of over 20 GBq.
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spelling pubmed-93177882022-07-27 Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi Pacelli, Anna Zarrad, Fadi Fendler, Wolfgang P. Herrmann, Ken Nader, Michael Pharmaceuticals (Basel) Article [(18)F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the previously reported protocol for [(18)F]PARPi synthesis is challenging, as it requires transferring microvolumes of reagents, which many platforms cannot accommodate. We report a revised, high yield, and automated protocol for the radiosynthesis of [(18)F]PARPi, with final doses of over 20 GBq. MDPI 2022-07-14 /pmc/articles/PMC9317788/ /pubmed/35890164 http://dx.doi.org/10.3390/ph15070865 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pacelli, Anna
Zarrad, Fadi
Fendler, Wolfgang P.
Herrmann, Ken
Nader, Michael
Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
title Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
title_full Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
title_fullStr Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
title_full_unstemmed Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
title_short Fully Automated, High-Dose Radiosynthesis of [(18)F]PARPi
title_sort fully automated, high-dose radiosynthesis of [(18)f]parpi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317788/
https://www.ncbi.nlm.nih.gov/pubmed/35890164
http://dx.doi.org/10.3390/ph15070865
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