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In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The success of LNPs is due to proprietary ionizable lipids and appropriate helper lipids. Using a benchmark lipid (D-Lin-MC3) we...

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Detalles Bibliográficos
Autores principales:	Medjmedj, Ayoub, Ngalle-Loth, Albert, Clemençon, Rudy, Hamacek, Josef, Pichon, Chantal, Perche, Federico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317807/ https://www.ncbi.nlm.nih.gov/pubmed/35889670 http://dx.doi.org/10.3390/nano12142446

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