Cargando…
Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound
Adiposity rebound (AR), which is defined as a situation in which the body mass index (BMI) starts to increase after infancy, is a predictive marker of future development of type 2 diabetes. The patient was a 20-year-old male. He was born at 28 gestational weeks with a birthweight of 642 g (−3.20 sta...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317845/ https://www.ncbi.nlm.nih.gov/pubmed/35886410 http://dx.doi.org/10.3390/ijerph19148560 |
_version_ | 1784755156472037376 |
---|---|
author | Nagano, Nobuhiko Kaneko, Chizuka Ohashi, Shoko Seya, Megumi Takigawa, Itsuro Masunaga, Ken Morioka, Ichiro |
author_facet | Nagano, Nobuhiko Kaneko, Chizuka Ohashi, Shoko Seya, Megumi Takigawa, Itsuro Masunaga, Ken Morioka, Ichiro |
author_sort | Nagano, Nobuhiko |
collection | PubMed |
description | Adiposity rebound (AR), which is defined as a situation in which the body mass index (BMI) starts to increase after infancy, is a predictive marker of future development of type 2 diabetes. The patient was a 20-year-old male. He was born at 28 gestational weeks with a birthweight of 642 g (−3.20 standard deviation, small-for-gestational age [SGA]). AR during early childhood or obesity in later childhood was not observed. At the onset of type 2 diabetes (20 years of age), his BMI, body fat percentage, and body fat mass were within normal ranges (20.4, 18.4% and 10.8 kg, respectively). However, his muscle mass was 44.7 kg, with low muscle mass of the trunk and upper limbs, which was lower than the standard reference, indicating that myogenic insulin resistance was involved in the development of non-obese type 2 diabetes. This case report describes a patient with no presentation of AR and obesity during childhood, who was born extremely preterm SGA, developed non-obese type 2 diabetes with low muscle mass. We suggest that patients born extremely preterm SGA should be carefully observed for the development of type 2 diabetes, even if they did not have AR in early childhood or had not become obese. |
format | Online Article Text |
id | pubmed-9317845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93178452022-07-27 Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound Nagano, Nobuhiko Kaneko, Chizuka Ohashi, Shoko Seya, Megumi Takigawa, Itsuro Masunaga, Ken Morioka, Ichiro Int J Environ Res Public Health Case Report Adiposity rebound (AR), which is defined as a situation in which the body mass index (BMI) starts to increase after infancy, is a predictive marker of future development of type 2 diabetes. The patient was a 20-year-old male. He was born at 28 gestational weeks with a birthweight of 642 g (−3.20 standard deviation, small-for-gestational age [SGA]). AR during early childhood or obesity in later childhood was not observed. At the onset of type 2 diabetes (20 years of age), his BMI, body fat percentage, and body fat mass were within normal ranges (20.4, 18.4% and 10.8 kg, respectively). However, his muscle mass was 44.7 kg, with low muscle mass of the trunk and upper limbs, which was lower than the standard reference, indicating that myogenic insulin resistance was involved in the development of non-obese type 2 diabetes. This case report describes a patient with no presentation of AR and obesity during childhood, who was born extremely preterm SGA, developed non-obese type 2 diabetes with low muscle mass. We suggest that patients born extremely preterm SGA should be carefully observed for the development of type 2 diabetes, even if they did not have AR in early childhood or had not become obese. MDPI 2022-07-13 /pmc/articles/PMC9317845/ /pubmed/35886410 http://dx.doi.org/10.3390/ijerph19148560 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Nagano, Nobuhiko Kaneko, Chizuka Ohashi, Shoko Seya, Megumi Takigawa, Itsuro Masunaga, Ken Morioka, Ichiro Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound |
title | Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound |
title_full | Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound |
title_fullStr | Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound |
title_full_unstemmed | Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound |
title_short | Non-Obese Type 2 Diabetes with a History of Being an Extremely Preterm Small-for-Gestational-Age Infant without Early Adiposity Rebound |
title_sort | non-obese type 2 diabetes with a history of being an extremely preterm small-for-gestational-age infant without early adiposity rebound |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317845/ https://www.ncbi.nlm.nih.gov/pubmed/35886410 http://dx.doi.org/10.3390/ijerph19148560 |
work_keys_str_mv | AT naganonobuhiko nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound AT kanekochizuka nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound AT ohashishoko nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound AT seyamegumi nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound AT takigawaitsuro nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound AT masunagaken nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound AT moriokaichiro nonobesetype2diabeteswithahistoryofbeinganextremelypretermsmallforgestationalageinfantwithoutearlyadiposityrebound |