Multi-Targeting Approach in Glioblastoma Using Computer-Assisted Drug Discovery Tools to Overcome the Blood–Brain Barrier and Target EGFR/PI3Kp110β Signaling

SIMPLE SUMMARY: Treatment of glioblastoma is hampered by the activation of compensatory survival mechanisms by malignant cells that lead to drug resistance. Moreover, the blood–brain barrier (BBB) precludes the brain entrance of most drugs. We hypothesized that computer-assisted drug discovery tools...

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Detalles Bibliográficos
Autores principales: Franco, Catarina, Kausar, Samina, Silva, Margarida F. B., Guedes, Rita C., Falcao, Andre O., Brito, Maria Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317902/
https://www.ncbi.nlm.nih.gov/pubmed/35884571
http://dx.doi.org/10.3390/cancers14143506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317902/
https://www.ncbi.nlm.nih.gov/pubmed/35884571
http://dx.doi.org/10.3390/cancers14143506

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