Cargando…

Multi-Targeting Approach in Glioblastoma Using Computer-Assisted Drug Discovery Tools to Overcome the Blood–Brain Barrier and Target EGFR/PI3Kp110β Signaling

SIMPLE SUMMARY: Treatment of glioblastoma is hampered by the activation of compensatory survival mechanisms by malignant cells that lead to drug resistance. Moreover, the blood–brain barrier (BBB) precludes the brain entrance of most drugs. We hypothesized that computer-assisted drug discovery tools...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franco, Catarina, Kausar, Samina, Silva, Margarida F. B., Guedes, Rita C., Falcao, Andre O., Brito, Maria Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317902/ https://www.ncbi.nlm.nih.gov/pubmed/35884571 http://dx.doi.org/10.3390/cancers14143506

Ejemplares similares

Overcoming EGFR inhibitor resistance in Glioblastoma by targeting co-amplified genes
por: Pant, Ayush, et al.
Publicado: (2023)

非小细胞肺癌PI3Kp110β高表达的临床意义及机制
Publicado: (2017)

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
por: Zhang, Lei, et al.
Publicado: (2020)

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells
por: El Haibi, Christelle P, et al.
Publicado: (2010)

Targeting immunoliposomes to EGFR-positive glioblastoma
por: Kasenda, B., et al.
Publicado: (2022)

Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments
por: Kwon, Yoojung, et al.
Publicado: (2019)

Proposal to study large-angle $Kp$ and $\pi p$ scattering
por: Carlson, Per J, et al.
Publicado: (1968)

EGFR and mTOR as therapeutic targets in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2019)

Proton fragmentation into pions and pion systems in Kp interactions at 110 GeV/c and comparison to model predictions
por: Krasny, Mieczyslaw Witek
Publicado: (2018)

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
por: Iqbal, Asneha, et al.
Publicado: (2016)

Transferrin Receptor-Targeted Nanocarriers: Overcoming Barriers to Treat Glioblastoma
por: Ramalho, Maria João, et al.
Publicado: (2022)

EGFR as a Target for Glioblastoma Treatment: An Unfulfilled Promise
por: Westphal, Manfred, et al.
Publicado: (2017)

An Overview of EGFR Mechanisms and Their Implications in Targeted Therapies for Glioblastoma
por: Rodriguez, Silvia Mara Baez, et al.
Publicado: (2023)

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma
por: Fianco, Giulia, et al.
Publicado: (2018)

Targeting the DNA Damage Response to Overcome Cancer Drug Resistance in Glioblastoma
por: Ferri, Alessandra, et al.
Publicado: (2020)

Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma
por: Grégoire, Hélène, et al.
Publicado: (2020)

DDRE-24. TARGETING PURINE METABOLISM TO OVERCOME GLIOBLASTOMA THERAPY RESISTANCE
por: Zhou, Weihua, et al.
Publicado: (2021)

Epidermal to Mesenchymal Transition and Failure of EGFR-Targeted Therapy in Glioblastoma
por: Pala, Andrej, et al.
Publicado: (2012)

Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma
por: Padfield, Emily, et al.
Publicado: (2015)

Anoctamins and Calcium Signalling: An Obstacle to EGFR Targeted Therapy in Glioblastoma?
por: Dewdney, Brittany, et al.
Publicado: (2022)

Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
por: d'Anglemont de Tassigny, Xavier, et al.
Publicado: (2017)

An automated framework for QSAR model building
por: Kausar, Samina, et al.
Publicado: (2018)

Analysis and Comparison of Vector Space and Metric Space Representations in QSAR Modeling
por: Kausar, Samina, et al.
Publicado: (2019)

A visual approach for analysis and inference of molecular activity spaces
por: Kausar, Samina, et al.
Publicado: (2019)

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma
por: Ravanpay, Ali C., et al.
Publicado: (2019)

Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages
por: Goulielmaki, Evangelia, et al.
Publicado: (2018)

Obituary – Dr. KP Srivastava
por: Pruthi, KK
Publicado: (2017)

Complete Genome Sequence of Klebsiella pneumoniae Bacteriophage KpS110, Encoding Five Tail-Associated Proteins with Putative Polysaccharide Depolymerase Domains
por: Volozhantsev, Nikolay V., et al.
Publicado: (2023)

Targeting EGFR and PI3K pathways in ovarian cancer
por: Glaysher, S, et al.
Publicado: (2013)

Correction: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2018)

Targeting Glioblastoma Stem Cells to Overcome Chemoresistance: An Overview of Current Therapeutic Strategies
por: Kang, Hyunkoo, et al.
Publicado: (2022)

Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy
por: Majkowska-Skrobek, Grażyna, et al.
Publicado: (2016)

Beyond EGFR Targeting in SCCHN: Angiogenesis, PI3K, and Other Molecular Targets
por: Saada-Bouzid, Esma, et al.
Publicado: (2019)

Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy
por: Orellana, Laura
Publicado: (2019)

Trials to Overcome Drug Resistance to EGFR and ALK Targeted Therapies – Past, Present, and Future
por: Spaans, Johanna N., et al.
Publicado: (2014)

Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance
por: Maity, Swastika, et al.
Publicado: (2020)

Co-Targeting the EGFR and PI3K/Akt Pathway to Overcome Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma: What about Autophagy?
por: Zaryouh, Hannah, et al.
Publicado: (2022)

Characterization of Klebsiella pneumoniae bacteriophages, KP1 and KP12, with deep learning-based structure prediction
por: Kim, Youngju, et al.
Publicado: (2023)

Inclusive production of $\pi^{0}$ mesons in $\pi$p, Kp and $\gamma$p collisions at energies around 100 GeV
por: Apsimon, R J, et al.
Publicado: (1991)

Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma
por: Yoshimoto, Koji, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hlrcjie3eeb6l1pg62v8v00fpf