Design, Synthesis, Docking, DFT, MD Simulation Studies of a New Nicotinamide-Based Derivative: In Vitro Anticancer and VEGFR-2 Inhibitory Effects

A nicotinamide-based derivative was designed as an antiproliferative VEGFR-2 inhibitor with the key pharmacophoric features needed to interact with the VEGFR-2 catalytic pocket. The ability of the designed congener ((E)-N-(4-(1-(2-(4-benzamidobenzoyl)hydrazono)ethyl)phenyl)nicotinamide), compound 10...

Descripción completa

Detalles Bibliográficos
Autores principales: Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317904/
https://www.ncbi.nlm.nih.gov/pubmed/35889478
http://dx.doi.org/10.3390/molecules27144606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317904/
https://www.ncbi.nlm.nih.gov/pubmed/35889478
http://dx.doi.org/10.3390/molecules27144606

Ejemplares similares