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Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review
The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide. Doxorubicin, an anticancer agent, is currently used to treat several types of ca...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318127/ https://www.ncbi.nlm.nih.gov/pubmed/35889350 http://dx.doi.org/10.3390/molecules27144478 |
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author | Peter, Sijongesonke Alven, Sibusiso Maseko, Rejoice Bethusile Aderibigbe, Blessing Atim |
author_facet | Peter, Sijongesonke Alven, Sibusiso Maseko, Rejoice Bethusile Aderibigbe, Blessing Atim |
author_sort | Peter, Sijongesonke |
collection | PubMed |
description | The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide. Doxorubicin, an anticancer agent, is currently used to treat several types of cancer. It disrupts myriad processes such as histone eviction, ceramide overproduction, DNA-adduct formation, reactive oxygen species generation, Ca(2+), and iron hemostasis regulation. However, its use is limited by factors such as drug resistance, toxicity, and congestive heart failure reported in some patients. The combination of doxorubicin with other chemotherapeutic agents has been reported as an effective treatment option for cancer with few side effects. Thus, the hybridization of doxorubicin and other chemotherapeutic drugs is regarded as a promising approach that can lead to effective anticancer agents. This review gives an update on hybrid compounds containing the scaffolds of doxorubicin and its derivatives with potent chemotherapeutic effects. |
format | Online Article Text |
id | pubmed-9318127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93181272022-07-27 Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review Peter, Sijongesonke Alven, Sibusiso Maseko, Rejoice Bethusile Aderibigbe, Blessing Atim Molecules Review The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide. Doxorubicin, an anticancer agent, is currently used to treat several types of cancer. It disrupts myriad processes such as histone eviction, ceramide overproduction, DNA-adduct formation, reactive oxygen species generation, Ca(2+), and iron hemostasis regulation. However, its use is limited by factors such as drug resistance, toxicity, and congestive heart failure reported in some patients. The combination of doxorubicin with other chemotherapeutic agents has been reported as an effective treatment option for cancer with few side effects. Thus, the hybridization of doxorubicin and other chemotherapeutic drugs is regarded as a promising approach that can lead to effective anticancer agents. This review gives an update on hybrid compounds containing the scaffolds of doxorubicin and its derivatives with potent chemotherapeutic effects. MDPI 2022-07-13 /pmc/articles/PMC9318127/ /pubmed/35889350 http://dx.doi.org/10.3390/molecules27144478 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Peter, Sijongesonke Alven, Sibusiso Maseko, Rejoice Bethusile Aderibigbe, Blessing Atim Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review |
title | Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review |
title_full | Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review |
title_fullStr | Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review |
title_full_unstemmed | Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review |
title_short | Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review |
title_sort | doxorubicin-based hybrid compounds as potential anticancer agents: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318127/ https://www.ncbi.nlm.nih.gov/pubmed/35889350 http://dx.doi.org/10.3390/molecules27144478 |
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