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Effects of the Interleukin-6 Receptor Blocker Sarilumab on Metabolic Activity and Differentiation Capacity of Primary Human Osteoblasts

Interleukin (IL-) 6 is a key factor in the inflammatory processes of rheumatoid arthritis. Several biologic agents target the IL-6 signaling pathway, including sarilumab, a monoclonal antibody that blocks the IL-6 receptor and inhibits IL-6-mediated cis- and trans-signaling. A careful analysis of th...

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Detalles Bibliográficos
Autores principales:	Klinder, Annett, Waletzko-Hellwig, Janine, Sellin, Marie-Luise, Seyfarth-Sehlke, Anika, Wolfien, Markus, Prehn, Franziska, Bader, Rainer, Jonitz-Heincke, Anika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318132/ https://www.ncbi.nlm.nih.gov/pubmed/35890286 http://dx.doi.org/10.3390/pharmaceutics14071390

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