A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson’s Disease

Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain endothelial cells have been used to shuttle antibodies and other cargos across the blood brain barrier (BBB) to the brain. For these studies the TXB4 brain shuttle was fused to a TrkB neurotrophin receptor agonist...

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Detalles Bibliográficos
Autores principales: Clarke, Emily, Stocki, Pawel, Sinclair, Elizabeth H., Gauhar, Aziz, Fletcher, Edward J. R., Krawczun-Rygmaczewska, Alicja, Duty, Susan, Walsh, Frank S., Doherty, Patrick, Rutkowski, Julia Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318160/
https://www.ncbi.nlm.nih.gov/pubmed/35890231
http://dx.doi.org/10.3390/pharmaceutics14071335

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