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Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population
COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318201/ https://www.ncbi.nlm.nih.gov/pubmed/35891149 http://dx.doi.org/10.3390/vaccines10070985 |
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author | Rabaan, Ali A. Bakhrebah, Muhammed A. Mutair, Abbas Al Alhumaid, Saad Al-Jishi, Jumana M. AlSihati, Jehad Albayat, Hawra Alsheheri, Ahmed Aljeldah, Mohammed Garout, Mohammed Alfouzan, Wadha A. Alhashem, Yousef N. AlBahrani, Salma Alshamrani, Saleh A. Alotaibi, Sultan AlRamadhan, Abdullah A. Albasha, Hanadi N. Hajissa, Khalid Temsah, Mohamad-Hani |
author_facet | Rabaan, Ali A. Bakhrebah, Muhammed A. Mutair, Abbas Al Alhumaid, Saad Al-Jishi, Jumana M. AlSihati, Jehad Albayat, Hawra Alsheheri, Ahmed Aljeldah, Mohammed Garout, Mohammed Alfouzan, Wadha A. Alhashem, Yousef N. AlBahrani, Salma Alshamrani, Saleh A. Alotaibi, Sultan AlRamadhan, Abdullah A. Albasha, Hanadi N. Hajissa, Khalid Temsah, Mohamad-Hani |
author_sort | Rabaan, Ali A. |
collection | PubMed |
description | COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed in infected patients post COVID-19 recovery. These health abnormalities, including is multiple organ failure—the most striking pathological features of COVID-19—have been linked with diverse distribution of ACE2 receptor. Additionally, several health complications reports were reported after administration of COVID-19 vaccines in healthy individuals, but clinical or molecular pathways causing such complications are not yet studied in detail. Thus, the present systematic review established the comparison of health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020–2022. This review also includes the biological rationale behind the COVID-19 infection and its subsequent symptoms and effects including multiorgan failure. In addition, multisystem inflammatory syndrome (MIS) has been informed in individuals post vaccination that resulted in multiorgan failure but, no direct correlation of vaccination with MIS has been established. Similarly, hemophagocytic lymphohistiocytosis (HLH) also noted to cause multiorgan failure in some individuals following full vaccination. Furthermore, severe complications were recorded in elderly patients (+40 years of age), indicates that older age individuals are higher risk by COVID-19 and post vaccination, but available literature is not sufficient to comply with any conclusive statements on relationship between vaccination and multiorgan failure. |
format | Online Article Text |
id | pubmed-9318201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93182012022-07-27 Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population Rabaan, Ali A. Bakhrebah, Muhammed A. Mutair, Abbas Al Alhumaid, Saad Al-Jishi, Jumana M. AlSihati, Jehad Albayat, Hawra Alsheheri, Ahmed Aljeldah, Mohammed Garout, Mohammed Alfouzan, Wadha A. Alhashem, Yousef N. AlBahrani, Salma Alshamrani, Saleh A. Alotaibi, Sultan AlRamadhan, Abdullah A. Albasha, Hanadi N. Hajissa, Khalid Temsah, Mohamad-Hani Vaccines (Basel) Review COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed in infected patients post COVID-19 recovery. These health abnormalities, including is multiple organ failure—the most striking pathological features of COVID-19—have been linked with diverse distribution of ACE2 receptor. Additionally, several health complications reports were reported after administration of COVID-19 vaccines in healthy individuals, but clinical or molecular pathways causing such complications are not yet studied in detail. Thus, the present systematic review established the comparison of health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020–2022. This review also includes the biological rationale behind the COVID-19 infection and its subsequent symptoms and effects including multiorgan failure. In addition, multisystem inflammatory syndrome (MIS) has been informed in individuals post vaccination that resulted in multiorgan failure but, no direct correlation of vaccination with MIS has been established. Similarly, hemophagocytic lymphohistiocytosis (HLH) also noted to cause multiorgan failure in some individuals following full vaccination. Furthermore, severe complications were recorded in elderly patients (+40 years of age), indicates that older age individuals are higher risk by COVID-19 and post vaccination, but available literature is not sufficient to comply with any conclusive statements on relationship between vaccination and multiorgan failure. MDPI 2022-06-21 /pmc/articles/PMC9318201/ /pubmed/35891149 http://dx.doi.org/10.3390/vaccines10070985 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rabaan, Ali A. Bakhrebah, Muhammed A. Mutair, Abbas Al Alhumaid, Saad Al-Jishi, Jumana M. AlSihati, Jehad Albayat, Hawra Alsheheri, Ahmed Aljeldah, Mohammed Garout, Mohammed Alfouzan, Wadha A. Alhashem, Yousef N. AlBahrani, Salma Alshamrani, Saleh A. Alotaibi, Sultan AlRamadhan, Abdullah A. Albasha, Hanadi N. Hajissa, Khalid Temsah, Mohamad-Hani Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
title | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
title_full | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
title_fullStr | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
title_full_unstemmed | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
title_short | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
title_sort | systematic review on pathophysiological complications in severe covid-19 among the non-vaccinated and vaccinated population |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318201/ https://www.ncbi.nlm.nih.gov/pubmed/35891149 http://dx.doi.org/10.3390/vaccines10070985 |
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