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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations

(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in particular, CAs IX and XII isoforms are overexpressed in numerous tumors. (2) Methods: following the tail approach, we have appended a hydrophobic aromatic tail to a pharmacophore res...

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Detalles Bibliográficos
Autores principales:	Arrighi, Giulia, Puerta, Adrián, Petrini, Andrea, Hicke, Francisco J., Nocentini, Alessio, Fernandes, Miguel X., Padrón, José M., Supuran, Claudiu T., Fernández-Bolaños, José G., López, Óscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318203/ https://www.ncbi.nlm.nih.gov/pubmed/35887037 http://dx.doi.org/10.3390/ijms23147685

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