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Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for the treatment of Parkinson’s disease. However, brain penetration of antibodies is hampered by their large size. Here, RmAbSynO2-scFv8D3, a modified bispecific antibody that targets aggregated αSYN and binds to the...

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Detalles Bibliográficos
Autores principales:	Roshanbin, Sahar, Julku, Ulrika, Xiong, Mengfei, Eriksson, Jonas, Masliah, Eliezer, Hultqvist, Greta, Bergström, Joakim, Ingelsson, Martin, Syvänen, Stina, Sehlin, Dag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318263/ https://www.ncbi.nlm.nih.gov/pubmed/35890306 http://dx.doi.org/10.3390/pharmaceutics14071412

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