Cargando…

Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin

Silymarin, a phyto-constituent derived from the plant Silybum marianum, has been widely acknowledged for its hepatoprotective activities. Nevertheless, its clinical utility is adversely hampered by its poor water-solubility and its limited oral bioavailability. The aim of this study was to investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shriram, Ravi Gundadka, Moin, Afrasim, Alotaibi, Hadil Faris, Khafagy, El-Sayed, Al Saqr, Ahmed, Abu Lila, Amr Selim, Charyulu, Rompicherla Narayana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318442/ https://www.ncbi.nlm.nih.gov/pubmed/35890088 http://dx.doi.org/10.3390/ph15070790

Ejemplares similares

Ocular Delivery of Bimatoprost-Loaded Solid Lipid Nanoparticles for Effective Management of Glaucoma
por: Satyanarayana, Sandeep Divate, et al.
Publicado: (2023)

Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats
por: Gohari Mahmoudabad, Arezoo, et al.
Publicado: (2023)

Biosynthesis of Silver Nanoparticles Using Commiphora mukul Extract: Evaluation of Anti-Arthritic Activity in Adjuvant-Induced Arthritis Rat Model
por: Singh, Anupama, et al.
Publicado: (2022)

Pulmonary Targeting of Levofloxacin Using Microsphere-Based Dry Powder Inhalation
por: Al Hagbani, Turki, et al.
Publicado: (2022)

Poly ε-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model
por: Singh, Ekta, et al.
Publicado: (2022)

Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation
por: Aldawsari, Mohammed F., et al.
Publicado: (2022)

Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis
por: Gopalakrishna, Poornima K., et al.
Publicado: (2023)

Antioxidant and Hepatoprotective Effect of a Nutritional Supplement with Silymarin Phytosome, Choline Chloride, l-Cystine, Artichoke, and Vitamin E in Dogs
por: Giannetto, Claudia, et al.
Publicado: (2022)

Development and Characterization of Pullulan-Based Orodispersible Films of Iron
por: Gupta, Maram Suresh, et al.
Publicado: (2023)

Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens
por: Rizvi, Syed Mohd Danish, et al.
Publicado: (2023)

Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes
por: Sharma, Sonam, et al.
Publicado: (2016)

In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives
por: Abu Lila, Amr Selim, et al.
Publicado: (2023)

Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin
por: Abdallah, Marwa H., et al.
Publicado: (2022)

Targeting silymarin for improved hepatoprotective activity through chitosan nanoparticles
por: Gupta, Swati, et al.
Publicado: (2014)

Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents
por: Lu, Mei, et al.
Publicado: (2019)

Dual targeting multiwalled carbon nanotubes for improved neratinib delivery in breast cancer
por: Abu Lila, Amr Selim, et al.
Publicado: (2023)

Hepatoprotective activity of silymarin encapsulation against hepatic damage in albino rats
por: Mukhtar, Shanza, et al.
Publicado: (2021)

Hepatoprotective effects of silymarin in management of liver injury caused by tuberculosis treatment
por: Lee, Yeong Yeh, et al.
Publicado: (2023)

Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art
por: Di Costanzo, Alfonso, et al.
Publicado: (2019)

Gold Nanoparticle-Based Resuscitation of Cefoxitin against Clinical Pathogens: A Nano-Antibiotic Strategy to Overcome Resistance
por: Alafnan, Ahmed, et al.
Publicado: (2022)

Nano-Conversion of Ineffective Cephalosporins into Potent One against Resistant Clinical Uro-Pathogens via Gold Nanoparticles
por: Rizvi, Syed Mohd Danish, et al.
Publicado: (2023)

Hepatoprotective Property of Oral Silymarin is Comparable to N-Acetyl Cysteine in Acetaminophen Poisoning
por: Kazemifar, Amir Mohammad, et al.
Publicado: (2012)

Hepatoprotective and renoprotective effects of silymarin against salinomycin-induced toxicity in adult rabbits
por: Ghonaim, Ahmed H., et al.
Publicado: (2022)

Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma
por: Aldawsari, Mohammed F., et al.
Publicado: (2021)

Enhancement of Vancomycin Potential against Pathogenic Bacterial Strains via Gold Nano-Formulations: A Nano-Antibiotic Approach
por: Hagbani, Turki Al, et al.
Publicado: (2022)

Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity
por: Al Hagbani, Turki, et al.
Publicado: (2022)

Formulation of Phytosomes with Extracts of Ginger Rhizomes and Rosehips with Improved Bioavailability, Antioxidant and Anti-Inflammatory Effects In Vivo
por: Deleanu, Mariana, et al.
Publicado: (2023)

Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats
por: Freitag, Abel Felipe, et al.
Publicado: (2015)

Hepatoprotective effects of silymarin on CCl(4)-induced hepatic damage in broiler chickens model
por: Baradaran, A., et al.
Publicado: (2019)

Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer
por: Moin, Afrasim, et al.
Publicado: (2021)

Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis
por: Vishwa, Bhavya, et al.
Publicado: (2021)

Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells
por: Rizzardi, Nicola, et al.
Publicado: (2021)

The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
por: Sornsuvit, Chuleegone, et al.
Publicado: (2018)

Screening of Apoptosis Pathway-Mediated Anti-Proliferative Activity of the Phytochemical Compound Furanodienone against Human Non-Small Lung Cancer A-549 Cells
por: Al Saqr, Ahmed, et al.
Publicado: (2022)

Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery
por: Khafagy, El-Sayed, et al.
Publicado: (2022)

Biofilm Lifestyle in Recurrent Urinary Tract Infections
por: Lila, Amr S. Abu, et al.
Publicado: (2023)

Hepatoprotective Effects of Silybum marianum (Silymarin) and Glycyrrhiza glabra (Glycyrrhizin) in Combination: A Possible Synergy
por: Rasool, Mahmood, et al.
Publicado: (2014)

Hepatoprotective Effect of Silver Nanoparticles at Two Different Particle Sizes: Comparative Study with and without Silymarin
por: Elfaky, Mahmoud A., et al.
Publicado: (2022)

Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins
por: Abu Lila, Amr Selim, et al.
Publicado: (2023)

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity
por: Song, Im-Sook, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kffe6pp2nqssare9g2jco0006d