Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

Melittin is a membrane-active peptide with strong anticancer activity against various cancers. Despite decades of research, the role of the singular Trp in the anticancer activity and selectivity of melittin remains poorly understood. Here, we propose a theranostic solution based on the substitution...

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Detalles Bibliográficos
Autores principales: Lv, Yonghui, Chen, Xu, Chen, Zhidong, Shang, Zhanjun, Li, Yongxiao, Xu, Wanting, Mo, Yuan, Wang, Xinpei, Xu, Daiyun, Li, Shengbin, Wang, Zhe, Wu, Meiying, Wang, Junqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318513/
https://www.ncbi.nlm.nih.gov/pubmed/35878166
http://dx.doi.org/10.3390/toxins14070428

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