Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm

Products containing nanomaterials are becoming more and more common in everyday life. Zinc oxide nanoparticles (ZnO NPs), meanwhile, are among the most widely used NPs. However, their genotoxic effect on the germ products of marine organisms is poorly understood. Therefore, the effects of ZnO NPs an...

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Detalles Bibliográficos
Autores principales: Kukla, Sergey Petrovich, Chelomin, Victor Pavlovich, Mazur, Andrey Alexandrovich, Slobodskova, Valentina Vladimirovna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318529/
https://www.ncbi.nlm.nih.gov/pubmed/35878253
http://dx.doi.org/10.3390/toxics10070348
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author Kukla, Sergey Petrovich
Chelomin, Victor Pavlovich
Mazur, Andrey Alexandrovich
Slobodskova, Valentina Vladimirovna
author_facet Kukla, Sergey Petrovich
Chelomin, Victor Pavlovich
Mazur, Andrey Alexandrovich
Slobodskova, Valentina Vladimirovna
author_sort Kukla, Sergey Petrovich
collection PubMed
description Products containing nanomaterials are becoming more and more common in everyday life. Zinc oxide nanoparticles (ZnO NPs), meanwhile, are among the most widely used NPs. However, their genotoxic effect on the germ products of marine organisms is poorly understood. Therefore, the effects of ZnO NPs and zinc ions (20, 50, 100, 200 µg/L) on the sperm of sand dollar Scaphechinus mirabilis were compared. Comet assay showed that both tested pollutants caused an increase in DNA damage to 6.57 ± 2.41 and 7.42 ± 0.88% DNA in the comet tail, for zinc ions and ZnO NPs, respectively. Additionally, a different pattern was shown by the increase in DNA damage, with increasing concentration of pollutants, in different experimental groups.
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spelling pubmed-93185292022-07-27 Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm Kukla, Sergey Petrovich Chelomin, Victor Pavlovich Mazur, Andrey Alexandrovich Slobodskova, Valentina Vladimirovna Toxics Article Products containing nanomaterials are becoming more and more common in everyday life. Zinc oxide nanoparticles (ZnO NPs), meanwhile, are among the most widely used NPs. However, their genotoxic effect on the germ products of marine organisms is poorly understood. Therefore, the effects of ZnO NPs and zinc ions (20, 50, 100, 200 µg/L) on the sperm of sand dollar Scaphechinus mirabilis were compared. Comet assay showed that both tested pollutants caused an increase in DNA damage to 6.57 ± 2.41 and 7.42 ± 0.88% DNA in the comet tail, for zinc ions and ZnO NPs, respectively. Additionally, a different pattern was shown by the increase in DNA damage, with increasing concentration of pollutants, in different experimental groups. MDPI 2022-06-24 /pmc/articles/PMC9318529/ /pubmed/35878253 http://dx.doi.org/10.3390/toxics10070348 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kukla, Sergey Petrovich
Chelomin, Victor Pavlovich
Mazur, Andrey Alexandrovich
Slobodskova, Valentina Vladimirovna
Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm
title Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm
title_full Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm
title_fullStr Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm
title_full_unstemmed Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm
title_short Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm
title_sort zinc oxide nanoparticles induce dna damage in sand dollar scaphechinus mirabilis sperm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318529/
https://www.ncbi.nlm.nih.gov/pubmed/35878253
http://dx.doi.org/10.3390/toxics10070348
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