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Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization

Antigenic imprinting, which describes the bias of the antibody response due to previous immune history, can influence vaccine effectiveness. While this phenomenon has been reported for viruses such as influenza, there is little understanding of how prior immune history affects the antibody response...

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Autores principales: Lv, Huibin, So, Ray T. Y., Teo, Qi Wen, Yuan, Meng, Liu, Hejun, Lee, Chang-Chun D., Yip, Garrick K., Ng, Wilson W., Wilson, Ian A., Peiris, Malik, Wu, Nicholas C., Mok, Chris Ka Pun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318566/
https://www.ncbi.nlm.nih.gov/pubmed/35891363
http://dx.doi.org/10.3390/v14071382
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author Lv, Huibin
So, Ray T. Y.
Teo, Qi Wen
Yuan, Meng
Liu, Hejun
Lee, Chang-Chun D.
Yip, Garrick K.
Ng, Wilson W.
Wilson, Ian A.
Peiris, Malik
Wu, Nicholas C.
Mok, Chris Ka Pun
author_facet Lv, Huibin
So, Ray T. Y.
Teo, Qi Wen
Yuan, Meng
Liu, Hejun
Lee, Chang-Chun D.
Yip, Garrick K.
Ng, Wilson W.
Wilson, Ian A.
Peiris, Malik
Wu, Nicholas C.
Mok, Chris Ka Pun
author_sort Lv, Huibin
collection PubMed
description Antigenic imprinting, which describes the bias of the antibody response due to previous immune history, can influence vaccine effectiveness. While this phenomenon has been reported for viruses such as influenza, there is little understanding of how prior immune history affects the antibody response to SARS-CoV-2. This study provides evidence for antigenic imprinting through immunization with two Sarbecoviruses, the subgenus that includes SARS-CoV-2. Mice were immunized subsequently with two antigenically distinct Sarbecovirus strains, namely SARS-CoV-1 and SARS-CoV-2. We found that sequential heterologous immunization induced cross-reactive binding antibodies for both viruses and delayed the emergence of neutralizing antibody responses against the booster strain. Our results provide fundamental knowledge about the immune response to Sarbecovirus and important insights into the development of pan-sarbecovirus vaccines and guiding therapeutic interventions.
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spelling pubmed-93185662022-07-27 Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization Lv, Huibin So, Ray T. Y. Teo, Qi Wen Yuan, Meng Liu, Hejun Lee, Chang-Chun D. Yip, Garrick K. Ng, Wilson W. Wilson, Ian A. Peiris, Malik Wu, Nicholas C. Mok, Chris Ka Pun Viruses Article Antigenic imprinting, which describes the bias of the antibody response due to previous immune history, can influence vaccine effectiveness. While this phenomenon has been reported for viruses such as influenza, there is little understanding of how prior immune history affects the antibody response to SARS-CoV-2. This study provides evidence for antigenic imprinting through immunization with two Sarbecoviruses, the subgenus that includes SARS-CoV-2. Mice were immunized subsequently with two antigenically distinct Sarbecovirus strains, namely SARS-CoV-1 and SARS-CoV-2. We found that sequential heterologous immunization induced cross-reactive binding antibodies for both viruses and delayed the emergence of neutralizing antibody responses against the booster strain. Our results provide fundamental knowledge about the immune response to Sarbecovirus and important insights into the development of pan-sarbecovirus vaccines and guiding therapeutic interventions. MDPI 2022-06-24 /pmc/articles/PMC9318566/ /pubmed/35891363 http://dx.doi.org/10.3390/v14071382 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lv, Huibin
So, Ray T. Y.
Teo, Qi Wen
Yuan, Meng
Liu, Hejun
Lee, Chang-Chun D.
Yip, Garrick K.
Ng, Wilson W.
Wilson, Ian A.
Peiris, Malik
Wu, Nicholas C.
Mok, Chris Ka Pun
Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
title Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
title_full Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
title_fullStr Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
title_full_unstemmed Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
title_short Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
title_sort neutralizing antibody response to sarbecovirus is delayed in sequential heterologous immunization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318566/
https://www.ncbi.nlm.nih.gov/pubmed/35891363
http://dx.doi.org/10.3390/v14071382
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