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Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants

In response to the fast-waning immune response and the great threat of the Omicron variant of concern (VOC) to the public, we report the pilot-scale production of an inactivated Omicron vaccine candidate that induces high levels of neutralizing antibody titers to protect against the Omicron virus. H...

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Autores principales: Zhang, Yuntao, Tan, Wenjie, Lou, Zhiyong, Zhao, Yuxiu, Zhang, Jin, Liang, Hongyang, Li, Na, Zhu, Xiujuan, Ding, Ling, Huang, Baoying, Zhou, Weimin, Guo, Yancen, Yang, Zhaona, Qiao, Yuling, He, Zhenyu, Ma, Bo, He, Yao, Zhu, Di, Wang, Zhanhui, Chang, Zhen, Zhao, Xue, Wang, Wei, Xu, Ying, Zhu, Huiqin, Zheng, Xiaotong, Wang, Chenlong, Xu, Guangxue, Wu, Guizhen, Wang, Hui, Yang, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318641/
https://www.ncbi.nlm.nih.gov/pubmed/35891313
http://dx.doi.org/10.3390/vaccines10071149
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author Zhang, Yuntao
Tan, Wenjie
Lou, Zhiyong
Zhao, Yuxiu
Zhang, Jin
Liang, Hongyang
Li, Na
Zhu, Xiujuan
Ding, Ling
Huang, Baoying
Zhou, Weimin
Guo, Yancen
Yang, Zhaona
Qiao, Yuling
He, Zhenyu
Ma, Bo
He, Yao
Zhu, Di
Wang, Zhanhui
Chang, Zhen
Zhao, Xue
Wang, Wei
Xu, Ying
Zhu, Huiqin
Zheng, Xiaotong
Wang, Chenlong
Xu, Guangxue
Wu, Guizhen
Wang, Hui
Yang, Xiaoming
author_facet Zhang, Yuntao
Tan, Wenjie
Lou, Zhiyong
Zhao, Yuxiu
Zhang, Jin
Liang, Hongyang
Li, Na
Zhu, Xiujuan
Ding, Ling
Huang, Baoying
Zhou, Weimin
Guo, Yancen
Yang, Zhaona
Qiao, Yuling
He, Zhenyu
Ma, Bo
He, Yao
Zhu, Di
Wang, Zhanhui
Chang, Zhen
Zhao, Xue
Wang, Wei
Xu, Ying
Zhu, Huiqin
Zheng, Xiaotong
Wang, Chenlong
Xu, Guangxue
Wu, Guizhen
Wang, Hui
Yang, Xiaoming
author_sort Zhang, Yuntao
collection PubMed
description In response to the fast-waning immune response and the great threat of the Omicron variant of concern (VOC) to the public, we report the pilot-scale production of an inactivated Omicron vaccine candidate that induces high levels of neutralizing antibody titers to protect against the Omicron virus. Here, we demonstrate that the inactivated Omicron vaccine is safe and effective in recalling immune responses to the HB02, Omicron, and Delta viruses after one or two doses of BBIBP-CorV. In addition, the efficient productivity and good genetic stability of the manufactured inactivated vaccine is proved. These results support the further evaluation of the Omicron vaccine in a clinical trial.
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spelling pubmed-93186412022-07-27 Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants Zhang, Yuntao Tan, Wenjie Lou, Zhiyong Zhao, Yuxiu Zhang, Jin Liang, Hongyang Li, Na Zhu, Xiujuan Ding, Ling Huang, Baoying Zhou, Weimin Guo, Yancen Yang, Zhaona Qiao, Yuling He, Zhenyu Ma, Bo He, Yao Zhu, Di Wang, Zhanhui Chang, Zhen Zhao, Xue Wang, Wei Xu, Ying Zhu, Huiqin Zheng, Xiaotong Wang, Chenlong Xu, Guangxue Wu, Guizhen Wang, Hui Yang, Xiaoming Vaccines (Basel) Article In response to the fast-waning immune response and the great threat of the Omicron variant of concern (VOC) to the public, we report the pilot-scale production of an inactivated Omicron vaccine candidate that induces high levels of neutralizing antibody titers to protect against the Omicron virus. Here, we demonstrate that the inactivated Omicron vaccine is safe and effective in recalling immune responses to the HB02, Omicron, and Delta viruses after one or two doses of BBIBP-CorV. In addition, the efficient productivity and good genetic stability of the manufactured inactivated vaccine is proved. These results support the further evaluation of the Omicron vaccine in a clinical trial. MDPI 2022-07-19 /pmc/articles/PMC9318641/ /pubmed/35891313 http://dx.doi.org/10.3390/vaccines10071149 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yuntao
Tan, Wenjie
Lou, Zhiyong
Zhao, Yuxiu
Zhang, Jin
Liang, Hongyang
Li, Na
Zhu, Xiujuan
Ding, Ling
Huang, Baoying
Zhou, Weimin
Guo, Yancen
Yang, Zhaona
Qiao, Yuling
He, Zhenyu
Ma, Bo
He, Yao
Zhu, Di
Wang, Zhanhui
Chang, Zhen
Zhao, Xue
Wang, Wei
Xu, Ying
Zhu, Huiqin
Zheng, Xiaotong
Wang, Chenlong
Xu, Guangxue
Wu, Guizhen
Wang, Hui
Yang, Xiaoming
Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
title Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
title_full Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
title_fullStr Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
title_full_unstemmed Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
title_short Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
title_sort vaccination with omicron inactivated vaccine in pre-vaccinated mice protects against sars-cov-2 prototype and omicron variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318641/
https://www.ncbi.nlm.nih.gov/pubmed/35891313
http://dx.doi.org/10.3390/vaccines10071149
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